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	MeMo: a web tool for prediction of protein methylation modifications
	Chen, Hu ; Xue, Yu ; Huang, Ni ; Yao, Xuebiao ; Sun, Zhirong
	2010-05-11 ; 2010-05-11
关键词	ARGININE METHYLATION HISTONE METHYLATION LYSINE METHYLATION PROTEOMIC ANALYSIS FAMILY SITES COMPLEXES TISSUE MEMBER Biochemistry & Molecular Biology
中文摘要	Protein methylation is an important and reversible post-translational modification of proteins (PTMs), which governs cellular dynamics and plasticity. Experimental identification of the methylation site is labor-intensive and often limited by the availability of reagents, such as methyl-specific antibodies and optimization of enzymatic reaction. Computational analysis may facilitate the identification of potential methylation sites with ease and provide insight for further experimentation. Here we present a novel protein methylation prediction web server named MeMo, protein methylation modification prediction, implemented in Support Vector Machines (SVMs). Our present analysis is primarily focused on methylation on lysine and arginine, two major protein methylation sites. However, our computational platform can be easily extended into the analyses of other amino acids. The accuracies for prediction of protein methylation on lysine and arginine have reached 67.1 and 86.7%, respectively. Thus, the MeMo system is a novel tool for predicting protein methylation and may prove useful in the study of protein methylation function and dynamics. The MeMo web server is available at: http://www.bioinfo.tsinghua.edu.cn/similar to tigerchen/memo.html.
语种	英语 ; 英语
出版者	OXFORD UNIV PRESS ; OXFORD ; GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26956]
专题	清华大学
推荐引用方式 GB/T 7714	Chen, Hu,Xue, Yu,Huang, Ni,et al. MeMo: a web tool for prediction of protein methylation modifications[J],2010, 2010.
APA	Chen, Hu,Xue, Yu,Huang, Ni,Yao, Xuebiao,&Sun, Zhirong.(2010).MeMo: a web tool for prediction of protein methylation modifications..
MLA	Chen, Hu,et al."MeMo: a web tool for prediction of protein methylation modifications".(2010).

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