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	Characterization and expression pattern of two zebrafish atf7 genes
	Zhao, CT ; Qi, JJ ; Meng, AM
	2010-05-11 ; 2010-05-11
关键词	zebrafish mammalian embryo notochord expression pattern activating transcription factor ATF7 TRANSCRIPTION FACTOR OASIS LONG-TERM-MEMORY ATF/CREB FAMILY CREB/ATF FAMILY MICE JUN APOPTOSIS PROTEIN FOS INHIBITION Anatomy & Morphology Developmental Biology
中文摘要	Members of the ATF/CREB (activating transcription factor/cAMP-responsive element binding protein) transcription factor family play diverse roles in controlling cell proliferation, apoptosis, and oncogenesis, as well as in embryonic development of vertebrates. We identified two zebrafish orthologs of human ATF7 gene: atf7a and atf7b. Whole-mount in situ hybridization shows that zebrafish atf7a is first expressed in the notochord precursors at 80% epiboly stage and then in the developing notochord during segmentation. The expression of atf7a is positively regulated by ntl, flh, and spr2, which are involved in development of the notochord. In contrast, atf7b is maternally expressed and during embryogenesis its mRNA is ubiquitously distributed, showing an expression pattern similar to that of mammalian Atf7. (c) 2005 Wiley-Liss, Inc.
语种	英语 ; 英语
出版者	WILEY-LISS ; HOBOKEN ; DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26934]
专题	清华大学
推荐引用方式 GB/T 7714	Zhao, CT,Qi, JJ,Meng, AM. Characterization and expression pattern of two zebrafish atf7 genes[J],2010, 2010.
APA	Zhao, CT,Qi, JJ,&Meng, AM.(2010).Characterization and expression pattern of two zebrafish atf7 genes..
MLA	Zhao, CT,et al."Characterization and expression pattern of two zebrafish atf7 genes".(2010).

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