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	Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: A possible mechanism in sporadic Wilms' tumor
	Rong, Yu ; Cheng, Long ; Ning, Hongxiu ; Zou, Jizhen ; Zhang, Yuanjiang ; Xu, Fang ; Lin, Li ; Chang, Zhijie ; Fu, Xin-Yuan
	2010-05-11 ; 2010-05-11
关键词	SUPPRESSOR GENE CONSTITUTIVE ACTIVATION SRC ONCOPROTEIN POOR-PROGNOSIS DNA-BINDING WT1 GENE GROWTH STAT3 PROTEINS KIDNEY Oncology
中文摘要	Transcription factor Wilms' tumor 1 (WT1) was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells, suggesting a potential oncogenic function of WT1. It is important to understand molecular mechanisms underlying these dual functions of WT1 in tumorigenesis. In the current study, we report a synergistic role for signal transducers and activators of transcription 3 (STAT3) and WT1 in tumor development, including Wilms' tumor. STAT3 interacts with WT1 through its conserved domains both in vitro and in vivo. When STAT3 is activated, expression of WT1 enhances STAT3 transcriptional activity. Overexpression of WT1 and STAT3CA in NIH 3T3 increases the expression level of STAT3 target genes, including cyclin D1 and Bcl-xL, which results in an advantage of cell proliferation. Our results suggest that in the presence of activated STAT3, WT1 promotes cell proliferation instead of suppressing cell proliferation. Strikingly, STAT3 translocates to the nucleus and interacts with WT1 in a variety of primary Wilms' tumor cells, raising the hypothesis that WT1 and activated STAT3 in Wilms' tumor accelerate tumorigenesis.
语种	英语 ; 英语
出版者	AMER ASSOC CANCER RESEARCH ; PHILADELPHIA ; 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26888]
专题	清华大学
推荐引用方式 GB/T 7714	Rong, Yu,Cheng, Long,Ning, Hongxiu,et al. Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: A possible mechanism in sporadic Wilms' tumor[J],2010, 2010.
APA	Rong, Yu.,Cheng, Long.,Ning, Hongxiu.,Zou, Jizhen.,Zhang, Yuanjiang.,...&Fu, Xin-Yuan.(2010).Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: A possible mechanism in sporadic Wilms' tumor..
MLA	Rong, Yu,et al."Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: A possible mechanism in sporadic Wilms' tumor".(2010).

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