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	Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila
	Qian, Meng ; Pan, Guohui ; Sun, Lu ; Feng, Chunhua ; Xie, Zuoping ; Tully, Tim ; Zhong, Yi
	2010-05-11 ; 2010-05-11
关键词	PTP10D long-term memory mushroom bodies chi behavior screen MOTOR AXON GUIDANCE CONSOLIDATED MEMORY SYNAPTIC PLASTICITY MICE LACKING WATER MAZE EMBRYO LOCALIZATION MELANOGASTER CNS Neurosciences
中文摘要	Tyrosine phosphorylation mediates multiple signal transduction pathways that play key roles in developmental processes and behavioral plasticity. The level of tyrosine phosphorylation is regulated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Extensive studies have investigated the roles of tyrosine kinases in memory formation. However, there were few studies on PTPs. To date, learning has been shown to be defective only for mouse knock-outs of PTP alpha, leukocyte common antigen-related, or PTP delta. A major limitation of these studies arises from their inability to distinguish an acute ( biochemical) impairment of memory formation from a more chronic abnormality in neurodevelopment. From a behavioral screen for defective long-term memory, we found chi mutants to disrupt expression of the PTP10D protein tyrosine phosphatase gene. We show that chi mutants are normal for learning, early memory, and anesthesia-resistant memory, whereas long-term memory specifically is abolished. Significantly, induction of a heat shock-PTP10D(+) transgene before training fully rescues the memory defect of chi mutants, thereby demonstrating an acute role for PTP10D in behavioral plasticity. We show that PTP10D is widely expressed in the embryonic CNS and in the adult brain. Transgenic expression of upstream activating sequence-PTP10D(+) in mushroom bodies is sufficient to rescue the memory defect of chi mutants. Our data clearly demonstrate that signaling through PTP10D in mushroom bodies is critical for the formation of long-term memory.
语种	英语 ; 英语
出版者	SOC NEUROSCIENCE ; WASHINGTON ; 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26870]
专题	清华大学
推荐引用方式 GB/T 7714	Qian, Meng,Pan, Guohui,Sun, Lu,et al. Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila[J],2010, 2010.
APA	Qian, Meng.,Pan, Guohui.,Sun, Lu.,Feng, Chunhua.,Xie, Zuoping.,...&Zhong, Yi.(2010).Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila..
MLA	Qian, Meng,et al."Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila".(2010).

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