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	Detecting robust gene signature through integrated analysis of multiple types of high-throughput data in liver cancer
	Zhang, Xin-yu ; Li, Tian-tian ; Liu, Xiang-jun
	2010-05-11 ; 2010-05-11
关键词	liver cancer integrated analysis robust gene signature gene expression map microarray SAGE HUMAN GENOME MICROARRAYS EXPRESSION Chemistry, Multidisciplinary Pharmacology & Pharmacy
中文摘要	Aim: To investigate the robust gene signature in liver cancer, we applied an integrated approach to perform a joint analysis of a highly diverse collection of liver cancer genome-wide datasets, including genomic alterations and transcription profiles. Methods: 1-class Significance Analysis of Microarrays coupled with ranking score method were used to identify the robust gene signature in liver tumor tissue. Results: In total, 1 625 051 gene expression measurements from 16 public microarrays, 2 pairs of serial analyses of gene expression experiments, and 252 loss of heterozygosity reports obtained from 568 publications were used in this integrated study. The resulting robust gene signatures included 90 genes, which may be of great importance to liver cancer research. A system assessment analysis revealed that our integrative method had an accuracy of 92% and a correlation coefficient value of 0.88. Conclusion: The system assessment results indicated that our method had the ability of integrating the datasets from various types of sources, and eliciting more accurate results, as can be very useful in the study of liver cancer.
语种	英语 ; 英语
出版者	BLACKWELL PUBLISHING ; OXFORD ; 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26859]
专题	清华大学
推荐引用方式 GB/T 7714	Zhang, Xin-yu,Li, Tian-tian,Liu, Xiang-jun. Detecting robust gene signature through integrated analysis of multiple types of high-throughput data in liver cancer[J],2010, 2010.
APA	Zhang, Xin-yu,Li, Tian-tian,&Liu, Xiang-jun.(2010).Detecting robust gene signature through integrated analysis of multiple types of high-throughput data in liver cancer..
MLA	Zhang, Xin-yu,et al."Detecting robust gene signature through integrated analysis of multiple types of high-throughput data in liver cancer".(2010).

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