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	The positively charged residues in the fragment 71-77 of complexin is required for its binding to SNARE complex
	Liu, Jingguo ; Wei, Yong ; Guo, Ting ; Xie, Xin ; Jiang, Jiansen ; Sui, Sen-fang
	2010-05-11 ; 2010-05-11
关键词	complexin SNARE complex interaction positively charged residues fluorescence resonance energy transfer MEMBRANE-FUSION NEUROTRANSMITTER RELEASE VESICLE EXOCYTOSIS SYNAPSES PROTEINS ROLES Biochemistry & Molecular Biology Cell Biology
中文摘要	Complexin is a cytoplasmic protein that plays an important role in the neurotransmitters release triggered by action potential. Previous studies suggested that complexin performs its functions through interaction with the SNARE complex. The crystal structure of complexin/SNARE complex revealed that complexin binds to SNARE core complex in an anti-parallel conformation with its residues 48-70. However, the functions of the flanking sequences are unclear. In this paper, we demonstrate that the fragment 71-77 of complexin is indispensable for its binding to the SNARE complex. Moreover, this interaction can be impaired by abolishing the positive charges in the fragment 71-77, which suggests that the positive charges in the fragment 71-77 are important for the interaction between complexin It and the SNARE complex.
语种	英语 ; 英语
出版者	TAYLOR & FRANCIS INC ; PHILADELPHIA ; 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26760]
专题	清华大学
推荐引用方式 GB/T 7714	Liu, Jingguo,Wei, Yong,Guo, Ting,et al. The positively charged residues in the fragment 71-77 of complexin is required for its binding to SNARE complex[J],2010, 2010.
APA	Liu, Jingguo,Wei, Yong,Guo, Ting,Xie, Xin,Jiang, Jiansen,&Sui, Sen-fang.(2010).The positively charged residues in the fragment 71-77 of complexin is required for its binding to SNARE complex..
MLA	Liu, Jingguo,et al."The positively charged residues in the fragment 71-77 of complexin is required for its binding to SNARE complex".(2010).

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