| Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes | |
| Dong, XN ; Ying, H ; Wu, Y ; Chen, YH | |
| 2010-05-11 ; 2010-05-11 | |
| 关键词 | HIV-1 gp41 genetic variability subtype neutralizing epitopes HUMAN-IMMUNODEFICIENCY-VIRUS HUMAN MONOCLONAL-ANTIBODY ENVELOPE GLYCOPROTEIN TYPE-1 EPITOPE RECOGNIZES MUTATION REGION FUSION MOTIF Immunology |
| 中文摘要 | Several neutralizing determinants have been identified on HIV-1 envelope glycoprotein gp41: LGIWGCSGKLIC (HXB2: aa593-604), ELDKWA (aa662-667), NWFDIT (aa671-676), and ERDRDR (aa739-744). Restricted mutations were observed on these epitopes. In this study, the genetic variability of these neutralizing determinants in 3799 isolates from different M-group subtypes (A, B, C, D, F, G, H, CRF01_AE and CRF02_AG) and 0 group was analyzed. Many variants were found to be closely correlated with certain subtypes. These subtype-related variants could be recruited into the subtype identification and subtype-specific vaccine development. (c) 2005 Elsevier B.V. All rights reserved. |
| 语种 | 英语 ; 英语 |
| 出版者 | ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/26752]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Dong, XN,Ying, H,Wu, Y,et al. Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes[J],2010, 2010. |
| APA | Dong, XN,Ying, H,Wu, Y,&Chen, YH.(2010).Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes.. |
| MLA | Dong, XN,et al."Genetic variability of principal neutralizing determinants on HIV-1 gp41 and its correlation with subtypes".(2010). |
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