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	The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin
	Huang, Y ; Shi, H ; Zhou, H ; Song, X ; Yuan, S ; Luo, Y
	2010-05-11 ; 2010-05-11
关键词	SURFACE-EXPRESSED NUCLEOLIN CELL-SURFACE PERMEABILITY FACTOR IN-VIVO VEGF CYTOSKELETON RECEPTORS VESSELS TUMORS Hematology
中文摘要	Nucleolin, originally described as a nuclear protein, was recently found to be expressed on the surface of endothelial cells during angiogenic. However, the functions of cell-surface nucleolin in angiogenic remain mysterious. Here we report that upon endothelial cells adhering to extracellular matrix components, vascular endothelial growth factor (VEGF) mobilizes nucleolin from nucleus to cell surface. Functional blockage or downregulation of the expression of cell-surface nucleolin in endothelial cells significantly inhibits the migration of endothelial cells and prevents capillary-tubule formation. Moreover, nonmuscle myosin heavy chain 9 (MyH9), an actin-based motor protein, is identified as a nucleolin-binding protein. Subsequent studies reveal that MyH9 serves as a physical linker between nucleolin and cytoskeleton, thus modulating the translocation of nucleolin. Knocking down endogenous MyH9, specifically inhibiting myosin activity, or overexpressing functional deficient MyH9 disrupts the organization of cell-surface nucleolin and inhibits its angiogenic function. These studies indicate that VEGF, extracellular matrix, and intracellular motor protein MyH9 are all essential for the novel function of nucleolin in angiogenic.
语种	英语 ; 英语
出版者	AMER SOC HEMATOLOGY ; WASHINGTON ; 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26706]
专题	清华大学
推荐引用方式 GB/T 7714	Huang, Y,Shi, H,Zhou, H,et al. The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin[J],2010, 2010.
APA	Huang, Y,Shi, H,Zhou, H,Song, X,Yuan, S,&Luo, Y.(2010).The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin..
MLA	Huang, Y,et al."The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin".(2010).

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