| Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging | |
| Ma, Xinyong ; Wang, Qiang ; Jiang, Yaxin ; Xiao, Zeyu ; Fang, Xiaohong ; Chen, Ye-Guang | |
| 2010-05-11 ; 2010-05-11 | |
| 关键词 | single-molecule fluorescence imaging mobility TGF-beta 1 TGF-beta receptor lipid-raft GROWTH-FACTOR-BETA LIVING CELLS MEMBRANE MICROSCOPY SURFACE COMPLEX Biochemistry & Molecular Biology Biophysics |
| 中文摘要 | In this report, we investigated the lateral diffusion of transforming growth factor beta (TGF-beta) type I receptor (T beta RI) in living cells by imaging and tracking individual green fluorescent protein tagged T beta RI on the cell membrane. We found that when co-expressed with TGF-beta type 11 receptor (T beta RII), the mobility of T beta RI decreased significantly after TGF-beta 1 stimulation. However, in the cells that had been depleted of cholesterol with Nystatin or methyl-beta-cyclodextrin, the diffusion rate of T beta RI was not changed by TGF-beta 1 treatment. Our observations suggest that membrane lipid-rafts provide an environment that facilitates the association of T beta RI and T beta RII for cell signaling. (c) 2007 Elsevier Inc. All rights reserved. |
| 语种 | 英语 ; 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE ; SAN DIEGO ; 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/26687]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Ma, Xinyong,Wang, Qiang,Jiang, Yaxin,et al. Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging[J],2010, 2010. |
| APA | Ma, Xinyong,Wang, Qiang,Jiang, Yaxin,Xiao, Zeyu,Fang, Xiaohong,&Chen, Ye-Guang.(2010).Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging.. |
| MLA | Ma, Xinyong,et al."Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging".(2010). |
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