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	The AKAP Yu is required for olfactory long-term memory formation in Drosophila
	Lu, Yubing ; Lu, Yi-Sheng ; Shuai, Yichun ; Feng, Chunhua ; Tully, Tim ; Xie, Zuoping ; Zhong, Yi ; Zhou, Hai-Meng
	2010-05-11 ; 2010-05-11
关键词	A-kinase anchoring protein cAMP pathway mushroom body olfactory memory PROTEIN-KINASE-A MUSHROOM BODIES SIGNALING COMPLEXES SYNAPTIC PLASTICITY ANCHORING PROTEINS REGULATORY SUBUNIT MOLECULAR-BIOLOGY GENE LOCALIZATION MELANOGASTER Multidisciplinary Sciences
中文摘要	Extensive neurogenetic analysis has shown that memory formation depends critically on cAMP-protein kinase A (PKA) signaling. Details of how this pathway is involved in memory formation, however, remain to be fully elucidated. From a large-scale behavioral screen in Drosophila, we identified the yu mutant to be defective in one-day memory after spaced training. The yu mutation disrupts a gene encoding an A-kinase anchoring protein (AKAP). AKAPs comprise a family of proteins, which determine the subcellular localization of PKAs and thereby critically restrict cAMP signaling within a cell. Further behavioral characterizations revealed that long-term memory (LTM) was disrupted specifically in the yu mutant, whereas learning, short-term memory and anesthesia-resistant memory all appeared normal. Another independently isolated mutation of the yu gene failed to complement the LTM defect associated with the yu mutation, and this phenotypic defect could be rescued by induced acute expression of a yu(+) transgene, suggesting that yu functions physiologically during memory formation. AKAP Yu is expressed preferentially in the mushroom body (MB) neuroanatomical structure, and expression of a yu(+) transgene to the MB, but not to other brain regions, is sufficient to rescue the LTM defect of the yu mutant. These observations lead us to conclude that proper localization of PKA by Yu AKAP in MB neurons is required for the formation of LTM.
语种	英语 ; 英语
出版者	NATL ACAD SCIENCES ; WASHINGTON ; 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26684]
专题	清华大学
推荐引用方式 GB/T 7714	Lu, Yubing,Lu, Yi-Sheng,Shuai, Yichun,et al. The AKAP Yu is required for olfactory long-term memory formation in Drosophila[J],2010, 2010.
APA	Lu, Yubing.,Lu, Yi-Sheng.,Shuai, Yichun.,Feng, Chunhua.,Tully, Tim.,...&Zhou, Hai-Meng.(2010).The AKAP Yu is required for olfactory long-term memory formation in Drosophila..
MLA	Lu, Yubing,et al."The AKAP Yu is required for olfactory long-term memory formation in Drosophila".(2010).

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