| Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through mTOR | |
| Li, Ru-Xin ; Yu, Xin-Zhu ; Fu, Min ; Zong, Min ; Liu, Ru-Lin ; Xie, Zuo-Ping | |
| 2010-05-11 ; 2010-05-11 | |
| 关键词 | mTOR rapamycin insulin Ca2+ spike PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET RAPAMYCIN SIGNALING PATHWAY LONG-TERM POTENTIATION MAMMALIAN TARGET PROTEIN-SYNTHESIS NEURONAL DEVELOPMENT OSCILLATIONS TRANSLATION RECEPTORS MECHANISM Neurosciences |
| 中文摘要 | The atypical serine/threonine protein kinase, a mammalian target of rapamycin (mTOR), is believed to be essential to the regulation of cell growth and the functions of the central nervous system. By using calcium imaging and patch-clamping techniques to study the role of this signaling pathway in the activity of cultured hippocampal neurons, we found that rapamycin significantly reduces the spontaneous activities of network neurons as well as the efficacy of synaptic transmission through insulin-mTOR signaling pathway. Our study sheds light on understanding the role of mTOR signaling pathway in controlling the information processing of network neurons. (C) 2008 Elsevier Ireland Ltd. All rights reserved. |
| 语种 | 英语 ; 英语 |
| 出版者 | ELSEVIER IRELAND LTD ; CLARE ; ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/26656]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Li, Ru-Xin,Yu, Xin-Zhu,Fu, Min,et al. Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through mTOR[J],2010, 2010. |
| APA | Li, Ru-Xin,Yu, Xin-Zhu,Fu, Min,Zong, Min,Liu, Ru-Lin,&Xie, Zuo-Ping.(2010).Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through mTOR.. |
| MLA | Li, Ru-Xin,et al."Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through mTOR".(2010). |
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