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	Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate)
	Cao, WL ; Wang, AJ ; Jing, DH ; Gong, YD ; Zhao, NM ; Zhang, XF
	2010-05-11 ; 2010-05-11
关键词	chitosan poly(3-hydroxybutyrate) emulsion blending mechanical properties porous blended scaffold TISSUE BIOCOMPATIBILITY COMPOSITES COLLAGEN MATRIX CHITIN ACID) Engineering, Biomedical Materials Science, Biomaterials Polymer Science
中文摘要	In order to develop a novel biomaterial, films of chitosan blended with poly(3-hydroxybutyrate) (PHB) were prepared by an emulsion blending technique and their properties were characterized. Scanning electron microscopy (SEM) showed that PHB microspheres were formed and were entrapped in chitosan matrices, which made the film surface rough. With increasing PHB content, the roughness of the film surface increased, while the swelling capability of the films decreased. In a wet state, the blended films exhibited a lower elastic modulus, a higher elongation-at-break and a higher tensile strength compared with chitosan films. Cell-culture experiments revealed that the blended films had better cytocompatibility than chitosan films. To explore the potential application of the blended material in tissue engineering, the porous blended scaffolds were fabricated and their pore morphology was observed by SEM. The results revealed that not only pore structure but also pore wall morphology of the blended scaffolds could be controlled by selecting the parameters of the fabrication process. These advantageous properties indicate that the blended chitosan/PHB material is promising for tissue engineering applications.
语种	英语 ; 英语
出版者	VSP BV ; LEIDEN ; BRILL ACADEMIC PUBLISHERS, PO BOX 9000, 2300 PA LEIDEN, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26636]
专题	清华大学
推荐引用方式 GB/T 7714	Cao, WL,Wang, AJ,Jing, DH,et al. Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate)[J],2010, 2010.
APA	Cao, WL,Wang, AJ,Jing, DH,Gong, YD,Zhao, NM,&Zhang, XF.(2010).Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate)..
MLA	Cao, WL,et al."Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate)".(2010).

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