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	Phylogenetic and biochemical studies reveal a potential evolutionary origin of small heat shock proteins of animals from bacterial class A
	Fu, XM ; Jiao, WW ; Chang, ZY
	2010-05-11 ; 2010-05-11
关键词	chaperone small heat shock protein oligomer polydisperse monodisperse ALPHA-CRYSTALLIN CHAPERONE ACTIVITY SUBUNIT EXCHANGE QUATERNARY STRUCTURE METHANOCOCCUS-JANNASCHII MOLECULAR CHAPERONES OLIGOMER FORMATION IN-VITRO PLANTS COMPLEXES Biochemistry & Molecular Biology Evolutionary Biology Genetics & Heredity
中文摘要	Small heat shock proteins ( sHSPs), as one subclass of molecular chaperones, are important for cells to protect proteins under stress conditions. Unlike the large HSPs ( represented by Hsp60 and Hsp70), sHSPs are highly divergent in both primary sequences and oligomeric status, with their evolutionary relationships being unresolved. Here the phylogenetic analysis of a representative 51 sHSPs ( covering the six subfamilies: bacterial class A, bacterial class B, archae, fungi, plant, and animal) reveals a close relationship between bacterial class A and animal sHSPs which form an outgroup. Accumulating data indicate that the oligomers from bacterial class A and animal sHSPs appear to exhibit polydispersity, while those from the rest exhibit monodispersity. Together, the close evolutionary relationship and the similarity in oligomeric polydispersity between bacterial class A and animal sHSPs not only suggest a potential evolutionary origin of the latter from the former, but also imply that their oligomeric polydispersity is somehow a property determined by their primary sequences.
语种	英语 ; 英语
出版者	SPRINGER ; NEW YORK ; 233 SPRING STREET, NEW YORK, NY 10013 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26619]
专题	清华大学
推荐引用方式 GB/T 7714	Fu, XM,Jiao, WW,Chang, ZY. Phylogenetic and biochemical studies reveal a potential evolutionary origin of small heat shock proteins of animals from bacterial class A[J],2010, 2010.
APA	Fu, XM,Jiao, WW,&Chang, ZY.(2010).Phylogenetic and biochemical studies reveal a potential evolutionary origin of small heat shock proteins of animals from bacterial class A..
MLA	Fu, XM,et al."Phylogenetic and biochemical studies reveal a potential evolutionary origin of small heat shock proteins of animals from bacterial class A".(2010).

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