Dendroflorin retards the senescence of MRC-5 cells | |
Jin, Jinghua ; Liang, Yu ; Xie, Hong ; Zhang, Xue ; Yao, Xinsheng ; Wang, Zhao | |
2010-05-11 ; 2010-05-11 | |
关键词 | Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy |
中文摘要 | The influence of dendroflorin, a potentially active compound extracted from Dendrobium nobile, on cell growth and cell cycles was assessed in a human embryo lung fibroblastic MRC-5 cell line. An MTT assay indicated that dendroflorin benefits cell proliferation. Additionally, we used flow cytometry to examine the cell cycles in senescent MRC-5 cells after treatment with dendroflorin, discovering that dendroflorin could trigger cells in the G1 phase to enter the S phase. Further examination of intracellular ROS contents using DCFH-DA suggested that dendroflorin helps ROS degradation, partly elucidating the mechanism of its effects. All of the above results suggest that dendroflorin is a potential candidate with anti-senescence activity. |
语种 | 英语 ; 英语 |
出版者 | GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH ; ESCHBORN ; PHARMAZEUTISCCARL MANNICH STR 26, D-65760 ESCHBORN, GERMANY |
内容类型 | 期刊论文 |
源URL | [http://hdl.handle.net/123456789/26618] ![]() |
专题 | 清华大学 |
推荐引用方式 GB/T 7714 | Jin, Jinghua,Liang, Yu,Xie, Hong,et al. Dendroflorin retards the senescence of MRC-5 cells[J],2010, 2010. |
APA | Jin, Jinghua,Liang, Yu,Xie, Hong,Zhang, Xue,Yao, Xinsheng,&Wang, Zhao.(2010).Dendroflorin retards the senescence of MRC-5 cells.. |
MLA | Jin, Jinghua,et al."Dendroflorin retards the senescence of MRC-5 cells".(2010). |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论