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	Dendroflorin retards the senescence of MRC-5 cells
	Jin, Jinghua ; Liang, Yu ; Xie, Hong ; Zhang, Xue ; Yao, Xinsheng ; Wang, Zhao
	2010-05-11 ; 2010-05-11
关键词	Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy
中文摘要	The influence of dendroflorin, a potentially active compound extracted from Dendrobium nobile, on cell growth and cell cycles was assessed in a human embryo lung fibroblastic MRC-5 cell line. An MTT assay indicated that dendroflorin benefits cell proliferation. Additionally, we used flow cytometry to examine the cell cycles in senescent MRC-5 cells after treatment with dendroflorin, discovering that dendroflorin could trigger cells in the G1 phase to enter the S phase. Further examination of intracellular ROS contents using DCFH-DA suggested that dendroflorin helps ROS degradation, partly elucidating the mechanism of its effects. All of the above results suggest that dendroflorin is a potential candidate with anti-senescence activity.
语种	英语 ; 英语
出版者	GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH ; ESCHBORN ; PHARMAZEUTISCCARL MANNICH STR 26, D-65760 ESCHBORN, GERMANY
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26618]
专题	清华大学
推荐引用方式 GB/T 7714	Jin, Jinghua,Liang, Yu,Xie, Hong,et al. Dendroflorin retards the senescence of MRC-5 cells[J],2010, 2010.
APA	Jin, Jinghua,Liang, Yu,Xie, Hong,Zhang, Xue,Yao, Xinsheng,&Wang, Zhao.(2010).Dendroflorin retards the senescence of MRC-5 cells..
MLA	Jin, Jinghua,et al."Dendroflorin retards the senescence of MRC-5 cells".(2010).

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