QQ客服 官方微博 反馈留言

	Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons
	Rui, Yanfang ; Tiwari, Priyanka ; Xie, Zuoping ; Zheng, James Q.
	2010-05-11 ; 2010-05-11
关键词	A beta peptide Alzheimer's disease signal transduction actin calcium cAMP transport GLYCOGEN-SYNTHASE KINASE-3 LONG-TERM POTENTIATION ALZHEIMERS-DISEASE AXONAL-TRANSPORT OXIDATIVE STRESS PROTEIN 1-42 TAU-PROTEIN CELL-DEATH AGGREGATION ACTIVATION Neurosciences
中文摘要	Defects in axonal transport are often associated with a wide variety of neurological diseases including Alzheimer's disease (AD). beta-Amyloid (A beta) is a major component of neuritic plaques associated with pathological conditions of AD brains. Here, we report that a brief exposure of cultured hippocampal neurons to A beta molecules resulted in rapid and severe impairment of mitochondrial transport without inducing apparent cell death and significant morphological changes. Such acute inhibition of mitochondrial transport was not associated with a disruption of mitochondria potential nor involved aberrant cytoskeletal changes. A beta also did not elicit significant Ca2+ signaling to affect mitochondrial trafficking. However, stimulation of protein kinase A (PKA) by forskolin, cAMP analogs, or neuropeptides effectively alleviated the impairment. We also show that A beta inhibited mitochondrial transport by acting through glycogen synthase kinase 3 beta (GSK3 beta). Given that mitochondria are crucial organelles for many cellular functions and survival, our findings thus identify an important acute action of A beta molecules on nerve cells that could potentially contribute to various abnormalities of neuronal functions under AD conditions. Manipulation of GSK3 beta and PKA activities may represent a key approach for preventing and alleviating A beta cytotoxicity and AD pathological conditions.
语种	英语 ; 英语
出版者	SOC NEUROSCIENCE ; WASHINGTON ; 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26556]
专题	清华大学
推荐引用方式 GB/T 7714	Rui, Yanfang,Tiwari, Priyanka,Xie, Zuoping,et al. Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons[J],2010, 2010.
APA	Rui, Yanfang,Tiwari, Priyanka,Xie, Zuoping,&Zheng, James Q..(2010).Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons..
MLA	Rui, Yanfang,et al."Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons".(2010).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。