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	Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways
	Li, Peng ; Wang, Xiaojian ; Li, Nan ; Kong, Huabei ; Guo, Zhenhong ; Liu, Shuxun ; Cao, Xuetao
	2010-05-11 ; 2010-05-11
关键词	ovarian carcinoma phosphatidylethanolamine binding protein apoptosis TRAIL MAPK N-TERMINAL KINASE ALPHA-INDUCED APOPTOSIS GROWTH-FACTOR RECEPTOR KAPPA-B DEATH RECEPTORS TNF-FAMILY EXPRESSION RESISTANCE LIGAND GENE Medicine, Research & Experimental
中文摘要	Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of tumor cell lines but not typically in normal or nontransformed cells, which makes TRAIL a desirable therapeutic agent to fight cancer. Human phosphatidylethanolamine-binding protein 4 (hPEBP4) is a recently identified anti-apoptotic molecule and has been shown to be highly expressed in breast and ovarian cancer cells. We demonstrate that silencing of hPEBP4 in CaoV-3 ovarian cancer cells potentiates TRAIL-induced apoptosis. We found that endogenous hPEBP4 interacts with Raf-1 and MEK1 in TRAIL-treated CaoV-3 cells by co-immunoprecipitation analysis. Simultaneously, silencing of hPEBP4 in CaoV-3 cells enhances TRAIL-induced ERK and JNK activation. Moreover, the inhibitors of MEK1 or JNK can reduce hPEBP4-silence-induced TRAIL sensitivity. Therefore, silencing of hPEBP4 in CaoV-3 ovarian cancer promotes TRAIL-induced apoptosis, and the increased MAPK activation is required for the apoptosis sensitization. All these data indicate that silencing of hPEBP4, an important potential target, may be a promising approach for the treatment of ovarian cancer.
语种	英语 ; 英语
出版者	PROFESSOR D A SPANDIDOS ; ATHENS ; 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS 116 35, GREECE
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26511]
专题	清华大学
推荐引用方式 GB/T 7714	Li, Peng,Wang, Xiaojian,Li, Nan,et al. Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways[J],2010, 2010.
APA	Li, Peng.,Wang, Xiaojian.,Li, Nan.,Kong, Huabei.,Guo, Zhenhong.,...&Cao, Xuetao.(2010).Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways..
MLA	Li, Peng,et al."Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways".(2010).

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