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	A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering
	Zhang, L ; Ao, Q ; Wang, AJ ; Lu, GY ; Kong, LJ ; Gong, YD ; Zhao, NM ; Zhang, XF
	2010-05-11 ; 2010-05-11
关键词	chitosan blood vessel tissue engineering knitting tubular scaffold mechanical property IN-VITRO CELL RESPONSES CONTROLLED-RELEASE BIOMATERIALS DERIVATIVES FIBROBLASTS HEPARIN CHITIN FILMS Engineering, Biomedical Materials Science, Biomaterials
中文摘要	Many materials have been investigated in blood vessel tissue engineering, such as PGA, PLGA, P4HB. However, chitosan is not mentioned in the arena. This Study aimed to develop a chitosan-based tubular scaffold and examine its feasibility of being applied in this field. Briefly, a knitted chitosan tube was dipped into chitosan solution (2%, w/v) and dried, then its inner and outer Surface was mantled with a layer of chitosan/gelatin (4:1, w/w) complex solution, and then freeze-dehydrated. In vitro characterization showed that the scaffold had a wall of 1.0 mm in thickness with a sandwich structure, and a porosity of 81.2%. The pore diameter was 50-150 mu m and could be regulated by varying freezing conditions. The scaffold possessed proper swelling property, burst strength of almost 4000 mmHg, and high suture-retention strength. After degradation for 2 months, the scaffold could maintain enough mechanical strength with an average mass loss of 18.7%. Vascular smooth muscle cells could spread and grow very well on the scaffold. This study provided a novel method to fabricate chitosan and its complex into a tubular scaffold and demonstrated the feasibility of the scaffold employed in the field of blood vessel tissue engineering. (c) 2006 Wiley Periodicals, Inc.
语种	英语 ; 英语
出版者	WILEY-LISS ; HOBOKEN ; DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26476]
专题	清华大学
推荐引用方式 GB/T 7714	Zhang, L,Ao, Q,Wang, AJ,et al. A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering[J],2010, 2010.
APA	Zhang, L.,Ao, Q.,Wang, AJ.,Lu, GY.,Kong, LJ.,...&Zhang, XF.(2010).A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering..
MLA	Zhang, L,et al."A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering".(2010).

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