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	V3CTL epitope density in a single recombinant molecule antigen differentially affects the number and activity of primary and memory CD8(+) T cells
	Lu, Lu ; Zhu, Yun ; Diao, Junchen ; Wang, Zuguang ; Chen, Ying-Hua
	2010-05-11 ; 2010-05-11
关键词	epitope density V3CTL epitope T cell response HUMAN-IMMUNODEFICIENCY-VIRUS VACCINE DEVELOPMENT SYNTHETIC PEPTIDES PROTEIN MOLECULE DENDRITIC CELLS LYMPHOCYTES RESPONSES HIV-1 INDUCTION EXPRESSION Immunology Medicine, Research & Experimental Veterinary Sciences
中文摘要	Previous studies have found the close correlation between epitope density and epitope-specific response, which have shown that high epitope density in a single recombinant protein molecule significantly enhances the humoral response and protective immunity. However, it has not been determined whether this kind of high epitope density could also significantly influence T cell response. Based on this, a series of recombinant DNA and proteins were designed and prepared. Each molecule consists of various copy numbers of the V3 CTL epitope on HIV-1 gp120 (one, two, four and eight copies). Our results show clearly that different V3-epitope densities in just one single DNA or protein molecules have respectively different effects on the number and activity of both primary and memory T cells. Interestingly, this effect is more complex than that on the B cells: epitope density in one plasmid or protein antigen affects the number, not the cytotoxic avidity, of primary CD8(+) T cells, but affects both the number and cytotoxic avidity of memory CD8(+) T cells. It indicates epitope density in the antigen is an important consideration to optimize T cell response induction and may facilitate the development of effective T cell-based anti-virus vaccines. (c) 2007 Elsevier Ltd. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCI LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26457]
专题	清华大学
推荐引用方式 GB/T 7714	Lu, Lu,Zhu, Yun,Diao, Junchen,et al. V3CTL epitope density in a single recombinant molecule antigen differentially affects the number and activity of primary and memory CD8(+) T cells[J],2010, 2010.
APA	Lu, Lu,Zhu, Yun,Diao, Junchen,Wang, Zuguang,&Chen, Ying-Hua.(2010).V3CTL epitope density in a single recombinant molecule antigen differentially affects the number and activity of primary and memory CD8(+) T cells..
MLA	Lu, Lu,et al."V3CTL epitope density in a single recombinant molecule antigen differentially affects the number and activity of primary and memory CD8(+) T cells".(2010).

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