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	Methyl protodioscin induces G2/M cell cycle arrest and apoptosis. in HepG2 liver cancer cells
	Wang, Guanghui ; Chen, Haifeng ; Huang, Minghui ; Wang, Naili ; Zhang, Jinchao ; Zhang, Yaou ; Bai, Ganrong ; Fong, Wang-Fun ; Yang, Mengsu ; Yao, Xinsheng
	2010-05-11 ; 2010-05-11
关键词	methyl protodioscin G(2)/M arrest apoptosis COLLETTII VAR. HYPOGLAUCA BCL-2 PROTEIN FAMILY ANTINEOPLASTIC AGENTS PREGNANE GLYCOSIDE HEL CELLS DIOSGENIN DIFFERENTIATION SAPONINS RHIZOMES LINES Oncology
中文摘要	Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin 131 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER IRELAND LTD ; CLARE ; ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26372]
专题	清华大学
推荐引用方式 GB/T 7714	Wang, Guanghui,Chen, Haifeng,Huang, Minghui,et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis. in HepG2 liver cancer cells[J],2010, 2010.
APA	Wang, Guanghui.,Chen, Haifeng.,Huang, Minghui.,Wang, Naili.,Zhang, Jinchao.,...&Yao, Xinsheng.(2010).Methyl protodioscin induces G2/M cell cycle arrest and apoptosis. in HepG2 liver cancer cells..
MLA	Wang, Guanghui,et al."Methyl protodioscin induces G2/M cell cycle arrest and apoptosis. in HepG2 liver cancer cells".(2010).

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