QQ客服 官方微博 反馈留言

	The effect of survivin on multidrug resistance mediated by P-glycoprotein in MCF-7 and its adriamycin resistant cells
	Liu, Feng ; Xie, Zhen-Hua ; Cai, Guo-Ping ; Jiang, Yu-Yang
	2010-05-11 ; 2010-05-11
关键词	survivin P-glycoprotein multidrug resistance MCF-7 cell ANTI-APOPTOSIS GENE MESSENGER-RNA CANCER CELLS ANTICANCER DRUGS PROTEIN SURVIVIN EXPRESSION PROGNOSIS DIVISION BINDING FAS Pharmacology & Pharmacy
中文摘要	Although anticancer chemotherapeutic drugs have been designed to inhibit the growth of tumor cells, chemotherapy frequently fails due to the development of multidrug resistance (MDR). In this paper, the effect of survivin on multidrug resistance mediated by P-glycoprotein (Pop) was investigated in breast cancer cells. Overexpression of survivin in MCF-7 cells transfected with survivin expression vector pEGFP/survivin results in decreasing sensitivity to anticancer drugs and activation of Pop to export drug out of cells. Down regulation of survivin in MCF-7/adriamycin (ADR) transfected with RNAi directed against survivin vector psh1/survivin could increase the drug accumulation in cells by inhibiting Pop. Downregulation of the expression of the Pop with the specific inhibitor verapamil could markedly suppress the survivin mRNA expression, whereas the reverse impact was not observed. Survivin might modulate the turnover of Pop or transport by Pop in cells, which result in antiapoptosis and drug resistance. Our results suggest that survivin might play a key role in MDR in the presence of Pop, and this might represent a novel strategy for modulating MDR in cancer cells.
语种	英语 ; 英语
出版者	PHARMACEUTICAL SOC JAPAN ; TOKYO ; 2-12-15-201 SHIBUYA, SHIBUYA-KU, TOKYO, 150, JAPAN
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/26356]
专题	清华大学
推荐引用方式 GB/T 7714	Liu, Feng,Xie, Zhen-Hua,Cai, Guo-Ping,et al. The effect of survivin on multidrug resistance mediated by P-glycoprotein in MCF-7 and its adriamycin resistant cells[J],2010, 2010.
APA	Liu, Feng,Xie, Zhen-Hua,Cai, Guo-Ping,&Jiang, Yu-Yang.(2010).The effect of survivin on multidrug resistance mediated by P-glycoprotein in MCF-7 and its adriamycin resistant cells..
MLA	Liu, Feng,et al."The effect of survivin on multidrug resistance mediated by P-glycoprotein in MCF-7 and its adriamycin resistant cells".(2010).

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。