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	The frequency response of QCM in electrochemically characterizing the immobilization on gold electrode
	Yonggui Dong
	2010-05-10 ; 2010-05-10
关键词	Practical Experimental/ biosensors crystal resonators electrochemical electrodes electrochemical sensors electrochemistry electron probe analysis frequency response gold microbalances microsensors molecular biophysics quartz surface chemistry voltammetry (chemical analysis)/ QCM frequency response gold electrode immobilization molecule detection immobilized sensing film electrochemical biosensor electrochemical quartz crystal microbalance electrochemical system oligonucleotide probe mercaptohexyl group electrode surface cyclic voltammetry self-assembled monolayer 5 MHz/ A8280T Chemical sensors A8245 Electrochemistry and electrophoresis A8780B Biosensors A8715H Biomolecular dynamics, molecular probes, molecular pattern recognition A8280F Electrochemical analytical methods A0710C Micromechanical devices and systems B7230L Chemical sensors B7230J Biosensors B2860A Piezoelectric devices B7230M Microsensors B2575B Materials for micromechanical device technology/ frequency 5.0E+06 Hz
中文摘要	Since the detected molecule may probably attach to the uncovered surface, the coverage of the immobilized sensing film is very important for electrochemical biosensors. This is especially true for gold electrodes. One electrochemical quartz crystal microbalance (EQCM) approach is investigated for characterizing the coverage. A 5MHz QCM element is used together with an electrochemical system. During the electrochemical experiments, the frequency response of the QCM is recorded simultaneously with the electrochemical parameters. Three cases, the bare, the 6-mecapto-1-hexanol modified and the 16-mer oligonucleotide probe (with a mercaptohexyl group at the 5'-phosphate end) modified gold electrodes are investigated. The results indicate that the frequency is more sensitive than the electrochemical response to the surface coverage. It could be used to evaluate the clearness of the electrode surface before immobilization, or the surface coverage after immobilization. [All rights reserved Elsevier].
语种	英语 ; 英语
出版者	Elsevier ; Switzerland
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/24456]
专题	清华大学
推荐引用方式 GB/T 7714	Yonggui Dong. The frequency response of QCM in electrochemically characterizing the immobilization on gold electrode[J],2010, 2010.
APA	Yonggui Dong.(2010).The frequency response of QCM in electrochemically characterizing the immobilization on gold electrode..
MLA	Yonggui Dong."The frequency response of QCM in electrochemically characterizing the immobilization on gold electrode".(2010).

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