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	Biomechanical properties of tissue engineered vascular scaffolds of three-layered wall
	Tao Mei ; Zhang Lei ; Xiang Hu ; Lin Feng ; Lu Qing-Ping ; Zhou Jian-Ye
	2010-05-10 ; 2010-05-10
关键词	Practical Experimental/ biodegradable materials biomechanics biomedical materials blood vessels cellular biophysics dip coating multilayers polymer films porous materials spraying tissue engineering/ biomechanical properties tissue engineered vascular scaffolds biodegradable three-layered-wall tubular scaffolds in vivo blood vessels construction wall thickness effects porous poly(lactide-co-glycolide) layer compact polyurethane layer dip-coating spraying salt leaching method burst strength radial compliance suture retention strength 0.295 to 0.432 mm/ A8745B Mechanical properties of tissues and organs A8770M Biomedical materials A8725 Cellular biophysics/ size 2.95E-04 to 4.32E-04 m
中文摘要	The objective is to evaluate the main biomechanical properties of biodegradable three-layered-wall tubular scaffolds used for the ulterior in vivo construction of tissue engineered blood vessels and to study the influence of wall thickness on those mechanical properties. The tubular scaffolds of three-layered-wall (porous PLGA layer-compact PU layer-porous PLGA layer) were fabricated by using dip-coating/spraying combined with salt leaching method. The burst strength, the radial compliance and suture retention strength of the scaffolds were tested on self-made device. The wall thickness of the fabricated tubular scaffolds ranged from 0.295 mm to 0.432 mm, and their radial compliance 3.80%/100 mmHg~0.57%/100 mmHg, the burst strength 160 kPa~183 kPa, and suture retention strength 0.63N/needle~1.52N/needle. It is concluded that the wall thickness, especially the thickness of the middle layer, had great impact on the mechanical properties of the tubular scaffolds. The value of radial compliance was reduced rapidly while the burst strength and the suture retention strength were increased linearly with the wall thickness increased. Among all the tested samples, the scaffolds having a wall thickness of 0.295 mm exhibited the best mechanical properties that meet the mechanical requirements during the implantation in vivo as a tissue engineered blood vessel scaffold.
语种	中文 ; 中文
出版者	Chinese Soc. Biomed. Eng ; China
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/23886]
专题	清华大学
推荐引用方式 GB/T 7714	Tao Mei,Zhang Lei,Xiang Hu,et al. Biomechanical properties of tissue engineered vascular scaffolds of three-layered wall[J],2010, 2010.
APA	Tao Mei,Zhang Lei,Xiang Hu,Lin Feng,Lu Qing-Ping,&Zhou Jian-Ye.(2010).Biomechanical properties of tissue engineered vascular scaffolds of three-layered wall..
MLA	Tao Mei,et al."Biomechanical properties of tissue engineered vascular scaffolds of three-layered wall".(2010).

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