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	AFM study of hippocampal cells cultured on silicon wafers with nano-scale surface topograph
	Ma, J ; Liu, BF ; Xu, QY ; Cui, FZ
	2010-05-10 ; 2010-05-10
关键词	atomic force microscopy lateral friction neural cell silicon cell adherence ATOMIC-FORCE MICROSCOPY IN-VITRO NEURAL CELLS ADHESION NEURONS ELASTICITY CHIP Biophysics Chemistry, Physical Materials Science, Biomaterials
中文摘要	The rat hippocampal cells were selected as model to study the interaction between the neural cells and silicon substrates using atomic force microscopy (AFM). The hippocampal cells show tight adherence on silicon wafers with nano-scale surface topograph. The lateral friction force investigated by AFM shows significant increase on the boundary around the cellular body. It is considered to relate to the cytoskeleton and cellular secretions. After ultrasonic wash in ethanol and acetone step by step, the surface of silicon wafers was observed by AFM sequentially. We have found that the culture leftovers form tight porous networks and a monolayer on the silicon wafers. It is concluded that the leftovers overspreading on the silicon substrates are the base of cell adherence on such smooth inert surfaces. (c) 2005 Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/21419]
专题	清华大学
推荐引用方式 GB/T 7714	Ma, J,Liu, BF,Xu, QY,et al. AFM study of hippocampal cells cultured on silicon wafers with nano-scale surface topograph[J],2010, 2010.
APA	Ma, J,Liu, BF,Xu, QY,&Cui, FZ.(2010).AFM study of hippocampal cells cultured on silicon wafers with nano-scale surface topograph..
MLA	Ma, J,et al."AFM study of hippocampal cells cultured on silicon wafers with nano-scale surface topograph".(2010).

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