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	Preparation and characterization of biodegradable beta -TCP-based composite microspheres as bone tissue engineering scaffolds
	Qingfeng Zan ; Chen Wang ; Limin Dong ; Rui Liu ; Jiemo Tian
	2010-05-10 ; 2010-05-10
关键词	Experimental/ bioceramics biodegradable materials bone calcium compounds composite materials materials preparation particle size polymers scanning electron microscopy surface morphology tissue engineering/ biodegradable composite microspheres bone tissue engineering scaffolds beta -TCP-chitosan composite microspheres tricalcium phosphate biodegradability osteogenic property solid-in-water-in-oil emulsion cross-linking method surface morphology microstructure scanning electron microscopy bone repair 50 to 200 micron Ca/sub 3/(PO/sub 4/)/sub 2// A8770M Biomedical materials A8120N Preparation of cermets, ceramic and refractory composites A8120T Preparation of reinforced polymers and polymer-based composites A6820 Solid surface structure A6480G Microstructure/ size 5.0E-05 to 2.0E-04 m/ Ca3PO4/ss Ca3/ss PO4/ss O4/ss Ca/ss O/ss P/ss
中文摘要	Since a small globular particle was first used as support for three-dimensional (3D) growth of anchorage-dependent cells in suspended cultures, a variety of microspheres as tissue engineering scaffolds have been developed. In this paper, beta -TCP and chitosan were selected as the components of microspheres due to their biodegradability and osteogenic properties. The biodegradable beta -TCP/chitosan composite microspheres were prepared by a solid-in-water-in-oil (s/w/o) emulsion cross-linking method in this paper. The size distribution, surface morphology, and microstructure of the microspheres were evaluated. Scanning electron microscopy revealed that the size of the microspheres with good spherical morphology was distributed in the range of 50-200 mu m. In vitro immersion experiments were carried out to evaluate the degradability of the microspheres, and the results demonstrated that the chitosan/ beta -TCP composite microspheres were potential materials as tissue engineering scaffolds for bone repair.
语种	英语 ; 英语
出版者	Trans Tech Publications ; Switzerland
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/21147]
专题	清华大学
推荐引用方式 GB/T 7714	Qingfeng Zan,Chen Wang,Limin Dong,et al. Preparation and characterization of biodegradable beta -TCP-based composite microspheres as bone tissue engineering scaffolds[J],2010, 2010.
APA	Qingfeng Zan,Chen Wang,Limin Dong,Rui Liu,&Jiemo Tian.(2010).Preparation and characterization of biodegradable beta -TCP-based composite microspheres as bone tissue engineering scaffolds..
MLA	Qingfeng Zan,et al."Preparation and characterization of biodegradable beta -TCP-based composite microspheres as bone tissue engineering scaffolds".(2010).

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