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	Identification and comparison of motifs in brain-specific and muscle-specific alternative splicing
	Bi, Jianning ; Li, Yanda
	2010-05-10 ; 2010-05-10
会议名称	THEORY AND APPLICATIONS OF MODELS OF COMPUTATION, PROCEEDINGS ; 3rd International Conference on Theory and Applications of Models of Computation (TAMC 2006) ; Beijing, PEOPLES R CHINA ; Web of Science ; INSPEC
关键词	PRE-MESSENGER-RNA COMPUTATIONAL ANALYSIS SEQUENCES ELEMENTS CANCER INTRON SITES Computer Science, Theory & Methods
中文摘要	Regulatory elements are important to the regulation of tissue-specific alternative splicing. Here we report a genome-wide analysis of motifs involved in human brain-specific or muscle-specific alternative splicing. Comparing relative abundance of alternative splice forms based on Bayesian statistics, we identified many tissue-specific exon skipping events in normal or tumor samples from brain or muscle. Motifs possibly function in these events were subsequently distinguished using EM algorithm. Analyses of these motifs suggest that some exons are tissue-specifically skipped through a loop out mechanism and motif locations are sometimes important. Furthermore, comparison of motifs in normal and tumor samples suggests that there may exist different tumorigenesis mechanisms between brain and muscle. These results provide some insights into the regulation mechanism of alternative splicing and may throw light on cancer therapy.
会议录出版者	SPRINGER-VERLAG BERLIN ; BERLIN ; HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/20008]
专题	清华大学
推荐引用方式 GB/T 7714	Bi, Jianning,Li, Yanda. Identification and comparison of motifs in brain-specific and muscle-specific alternative splicing[C]. 见:THEORY AND APPLICATIONS OF MODELS OF COMPUTATION, PROCEEDINGS, 3rd International Conference on Theory and Applications of Models of Computation (TAMC 2006), Beijing, PEOPLES R CHINA, Web of Science, INSPEC.

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