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	Application of microbial polyesters-polyhydroxyalkanoates as tissue engineering materials
	Chen, GQ ; Wu, Q ; Wang, YW ; Zheng, Z
	2010-05-10 ; 2010-05-10
会议名称	ASBM6: ADVANCED BIOMATERIALS VI ; 6th Asian Symposium on Biomedical Materials (ASM6) ; Emei, PEOPLES R CHINA ; Web of Science ; INSPEC
关键词	polyhydroxyalkanoates PHB Aeromonas hydrophila biomaterials tissue engineering POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYHEXANOATE) BIOCOMPATIBILITY SCAFFOLDS PROLIFERATION CHONDROCYTES Materials Science, Ceramics Materials Science, Composites
中文摘要	Poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) has improved mechanical properties over the existing PHA and our results have shown that PHBHHx has better biocompatibility over polyhydroxybutyrate (PHB) and polylactic acid (PLA). Surface treatment with lipases dramatically changed the material surface properties and increased the biocompatibility of the PHBHHx. PHBHHx and its PHB blends had been used to make three dimensional structures and it has been found that cartilage, osteoblast, and fibroblasts all showed strong growth on the PHBHHx scaffolds. The growth was much better compared with PLA. The molecular studies also showed that mRNA encoding cartilages were strongly expressed when cartilage cells were grown on the PHBHHx. As PHBHHx has strong mechanical properties, easily processible and biodegradable, this material can be used to develop a new class of tissue engineering materials.
会议录出版者	TRANS TECH PUBLICATIONS LTD ; ZURICH-UETIKON ; BRANDRAIN 6, CH-8707 ZURICH-UETIKON, SWITZERLAND
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/20001]
专题	清华大学
推荐引用方式 GB/T 7714	Chen, GQ,Wu, Q,Wang, YW,et al. Application of microbial polyesters-polyhydroxyalkanoates as tissue engineering materials[C]. 见:ASBM6: ADVANCED BIOMATERIALS VI, 6th Asian Symposium on Biomedical Materials (ASM6), Emei, PEOPLES R CHINA, Web of Science, INSPEC.

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