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	Improvement of fibroblast adherence to titanium surface by calcium phosphate coating formed with IBAD
	Zhao, BH ; Lee, IS ; Bai, W ; Cui, FZ ; Feng, HL
	2010-05-10 ; 2010-05-10 ; SEP 28-OCT 03, 2003
会议名称	SURFACE & COATINGS TECHNOLOGY ; 4th Asian-European International Conference on Plasma Surface Engineering ; Jeju City, SOUTH KOREA ; Web of Science
关键词	TCP/HA IBAD cell attachment ECM focal adhesion plaque HYDROXYAPATITE COATINGS DENTAL IMPLANTS IN-VITRO HYDROXYLAPATITE COMPLICATIONS ATTACHMENT PROSTHESES ALLOY CELLS Materials Science, Coatings & Films Physics, Applied
中文摘要	Coatings of hydroxyapatite (HA) and duplex phases of tricalcium phosphate/hydroxyapatite (TCP/HA) on titanium (Ti) were formed by ion beam-assisted deposition (IBAD). Human gingival fibroblasts (HGFs) attachment, spreading, extracellular matrix (ECM) production, and focal adhesion plaque formation were investigated on commercially pure titanium (cpTi), HA-coated cpTi, and porous TCP/HA-coated cpTi. After standard cell culture of HGFs on these substrates, attached cell number, cell spreading area, immunostained ECM including fibronectin (FN) and type I collage, and vinculin (presenting the formation of focal adhesion plaque) were quantified by morphometric analysis using an immunofluorescence microscope. TCP/HA and HA coatings exhibited that attached cell number and cell spreading area were higher than that of cpTi, and focal adhesion plaque formed earlier than that of uncoated substrate. The attached cell number and type I collagen formation on TCP/HA were more than that on HA. These results showed that significant improvement of soft tissue adherence to Ti surface was obtained by the porous TCP/HA coating. This indicated that this surface modification method may enhance the biological seal at the cervical level of the Ti dental implants. (c) 2004 Elsevier B.V. All rights reserved.
会议录出版者	ELSEVIER SCIENCE SA ; LAUSANNE ; PO BOX 564, 1001 LAUSANNE, SWITZERLAND
语种	英语 ; 英语
内容类型	会议论文
源URL	[http://hdl.handle.net/123456789/18221]
专题	清华大学
推荐引用方式 GB/T 7714	Zhao, BH,Lee, IS,Bai, W,et al. Improvement of fibroblast adherence to titanium surface by calcium phosphate coating formed with IBAD[C]. 见:SURFACE & COATINGS TECHNOLOGY, 4th Asian-European International Conference on Plasma Surface Engineering, Jeju City, SOUTH KOREA, Web of Science.

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