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	Transdermal delivery of piroxicam by surfactant mediated electroporation
	Zan Jia ; Jiang Guoqiang ; Lin Ying ; Tan Fengping ; Ding Fuxin
	2010-05-07 ; 2010-05-07
关键词	Practical Experimental/ drug delivery systems drugs surfactants/ transdermal delivery piroxicam surfactant mediated electroporation nonsteroidal antiinflammation drug skin electroporation skin lipids entrapment lipophilic drugs sodium dodecyl sulphate hydrophobic local transport regions Tween 80/ A8770G Patient care and treatment
中文摘要	A lipophilic, nonsteroidal antiinflammation drug, piroxicam, was administered by skin electroporation using short, high-voltage pulses. The transdermal delivery of piroxicam during the electroporation was buffered due to the higher partition in skin lipids than in aqueous environments, which is called entrapment. Entrapment is the main resistance to transdermal delivery of lipophilic drugs. Two types of surfactants were used to enhance the skin electroporation. Tween 80 (0.2 g/L) and sodium dodecyl sulphate (SDS, 3 mg/mL) improve the solubility and diffusion rate of the drug in the hydrophobic local transport regions and reduce the entrapment of piroxicam in the skin. The transdermal delivery rate of piroxicam is increased 30- to 50-fold. However, the entrapment of piroxicam in the skin still occurred when Tween 80 was added. The SDS provides higher and more stable transdermal delivery rates of piroxicam than Tween 80, and also reduces the entrapment of piroxicam in the skin.
语种	英语 ; 英语
出版者	Editorial Board of J. of Tsinghua University ; China
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/17222]
专题	清华大学
推荐引用方式 GB/T 7714	Zan Jia,Jiang Guoqiang,Lin Ying,et al. Transdermal delivery of piroxicam by surfactant mediated electroporation[J],2010, 2010.
APA	Zan Jia,Jiang Guoqiang,Lin Ying,Tan Fengping,&Ding Fuxin.(2010).Transdermal delivery of piroxicam by surfactant mediated electroporation..
MLA	Zan Jia,et al."Transdermal delivery of piroxicam by surfactant mediated electroporation".(2010).

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