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	Prediction of collective diffusion coefficient of bovine serum albumin in aqueous electrolyte solution with hard-core two-Yukawa potential
	Yu, YX ; Tian, AW ; Gao, GH
	2010-05-07 ; 2010-05-07
关键词	CONCENTRATED PROTEIN SOLUTIONS 2 YUKAWA POTENTIALS OSMOTIC-PRESSURE LIGHT-SCATTERING COLLOIDAL PARTICLES IONIC-STRENGTH EQUATION SPHERES SEDIMENTATION FLUID Chemistry, Physical Physics, Atomic, Molecular & Chemical
中文摘要	A new method to predict concentration dependence of collective diffusion coefficient of bovine serum albumin (BSA) in aqueous electrolyte solution is developed based on the generalized Stokes-Einstein equation which relates the diffusion coefficient to the osmotic pressure. The concentration dependence of osmotic pressure is evaluated using the solution of the mean spherical approximation for the two-Yukawa model fluid. The two empirical correlations of sedimentation coefficient are tested in this work. One is for a disordered suspension of hard spheres, and another is for an ordered suspension of hard spheres. The concentration dependence of the collective diffusion coefficient of BSA under different solution conditions, such as pH and ionic strength is predicted. From the comparison between the predicted and experimental values we found that the sedimentation coefficient for the disordered suspension of hard spheres is more suitable for the prediction of the collective diffusion coefficients of charged BSA in aqueous electrolyte solution. The theoretical predictions from the hard-core two-Yukawa model coupled with the sedimentation coefficient for a suspension of hard spheres are in good agreement with available experimental data, while the hard sphere model is unable to describe the behavior of diffusion due to its neglect of the double-layer repulsive charge-charge interaction between BSA molecules.
语种	英语 ; 英语
出版者	ROYAL SOC CHEMISTRY ; CAMBRIDGE ; THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/17184]
专题	清华大学
推荐引用方式 GB/T 7714	Yu, YX,Tian, AW,Gao, GH. Prediction of collective diffusion coefficient of bovine serum albumin in aqueous electrolyte solution with hard-core two-Yukawa potential[J],2010, 2010.
APA	Yu, YX,Tian, AW,&Gao, GH.(2010).Prediction of collective diffusion coefficient of bovine serum albumin in aqueous electrolyte solution with hard-core two-Yukawa potential..
MLA	Yu, YX,et al."Prediction of collective diffusion coefficient of bovine serum albumin in aqueous electrolyte solution with hard-core two-Yukawa potential".(2010).

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