| Nonlinear mechanical modeling of cell adhesion | |
| Kong, Dong ; Ji, Baohua ; Dai, Lanhong | |
| 2010-05-07 ; 2010-05-07 | |
| 关键词 | cell adhesion focal adhesions nonlinear receptor-ligand bonds force-extension relationship bond density MEMBRANE-MEMBRANE ADHESION MOLECULAR CROSS-BRIDGES DETAILED MECHANICS FOCAL CONTACTS DETACHMENT KINETICS ACTIVATION ATTACHMENT SEPARATION NANOSCALE Biology Mathematical & Computational Biology |
| 中文摘要 | Cell adhesion, which is mediated by the receptor-ligand bonds, plays an essential role in various biological processes. Previous studies often described the force-extension relationship of receptor-ligand bond with linear assumption. However, the force-extension relationship of the bond is intrinsically nonlinear, which should have significant influence on the mechanical behavior of cell adhesion. In this work, a nonlinear mechanical model for cell adhesion is developed, and the adhesive strength was studied at various bond distributions. We find that the nonlinear mechanical behavior of the receptor-ligand bonds is crucial to the adhesive strength and stability. This nonlinear behavior allows more bonds to achieve large bond force simultaneously, and therefore the adhesive strength becomes less sensitive to the change of bond density at the outmost periphery of the adhesive area. In this way, the strength and stability of cell adhesion are soundly enhanced. The nonlinear model describes the cell detachment behavior better than the linear model. (C) 2007 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 ; 英语 |
| 出版者 | ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD ; LONDON ; 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/16265]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Kong, Dong,Ji, Baohua,Dai, Lanhong. Nonlinear mechanical modeling of cell adhesion[J],2010, 2010. |
| APA | Kong, Dong,Ji, Baohua,&Dai, Lanhong.(2010).Nonlinear mechanical modeling of cell adhesion.. |
| MLA | Kong, Dong,et al."Nonlinear mechanical modeling of cell adhesion".(2010). |
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