Scanning for signatures of geographically restricted selection based on population genomics analysis | |
Deng LiBin ; Tang XiaoLi ; Kang Jian ; Wang QingYun ; Zeng ChangQing | |
2010-05-06 ; 2010-05-06 ; OCT | |
关键词 | natural selection HapMap Project single nucleotide polymorphism population genomics gene ontology INTERNATIONAL HAPMAP PROJECT NATURAL-SELECTION POSITIVE SELECTION SEQUENCE VARIATION EVOLUTION GENE HUMANS SCANS HISTORY MAP Multidisciplinary Sciences |
中文摘要 | Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus F (ST) analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of F (ST), we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection. |
语种 | 英语 ; 英语 |
出版者 | SCIENCE CHINA PRESS ; BEIJING ; 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA |
内容类型 | 期刊论文 |
源URL | [http://hdl.handle.net/123456789/14300] ![]() |
专题 | 清华大学 |
推荐引用方式 GB/T 7714 | Deng LiBin,Tang XiaoLi,Kang Jian,et al. Scanning for signatures of geographically restricted selection based on population genomics analysis[J],2010, 2010, OCT. |
APA | Deng LiBin,Tang XiaoLi,Kang Jian,Wang QingYun,&Zeng ChangQing.(2010).Scanning for signatures of geographically restricted selection based on population genomics analysis.. |
MLA | Deng LiBin,et al."Scanning for signatures of geographically restricted selection based on population genomics analysis".(2010). |
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