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	In vitro monitoring of nanogram levels of naproxen in human urine using flow injection chemiluminescence
	Cheng, XL ; Zhao, LX ; Liu, ML ; Lin, JM
	2010-05-06 ; 2010-05-06
关键词	chemiluminescence naproxen urine flow injection analysis CHEMI-LUMINESCENCE TABLETS MEDIA Chemistry, Analytical
中文摘要	Based on the synergic effect of the hydrophobicity of sodium dodecylbenzenesulfonate (SDBS) micelles and the incorporation of naproxen molecules, a simple, rapid and sensitive chemiluminescence (CL) method was described for the determination of naproxen in pharmaceuticals and urine. Under the optimum experimental conditions, the CL intensity was linear over the concentration of naproxen ranging from 1.0 to 700.0 ng mL(-1) (r = 0.9917) with a detection limit as low as 0.9 ng mL(-1) (S/N = 3). The mechanism of CL was discussed in detail based on the spectrometry. The experimental results demonstrated that the excretive amounts of naproxen reached its maximum in 4.0 h after taking 200 mg naproxen tablet; and the naproxen excretive ratio during 8.0 h was 5.46% in the body of volunteers. (c) 2005 Elsevier B.V. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/13651]
专题	清华大学
推荐引用方式 GB/T 7714	Cheng, XL,Zhao, LX,Liu, ML,et al. In vitro monitoring of nanogram levels of naproxen in human urine using flow injection chemiluminescence[J],2010, 2010.
APA	Cheng, XL,Zhao, LX,Liu, ML,&Lin, JM.(2010).In vitro monitoring of nanogram levels of naproxen in human urine using flow injection chemiluminescence..
MLA	Cheng, XL,et al."In vitro monitoring of nanogram levels of naproxen in human urine using flow injection chemiluminescence".(2010).

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