| Identification of radiation-induced cross-linking between thymine and tryptophan by electrospray ionization-mass spectrometry | |
| Shi, Wei-Qun ; Hu, Jia ; Zhao, Wei ; Su, Xiao-Yang ; Cai, Hui ; Zhao, Yu-Fen ; Li, Yan-Mei | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | cross-linking tyrosine tryptophan thymine gamma radiation MAMMALIAN-CELLS CANCER-RISK DNA-DAMAGE TYROSINE NUCLEOHISTONE MECHANISM PRODUCTS PEPTIDES PROTEINS DISEASE Biophysics Chemistry, Organic Spectroscopy |
| 中文摘要 | Upon exposure to ionizing radiation, DNA undergoes a variety of modifications including the production of a covalent bond between the nucleobase thymine and aromatic amino acids. In this work, electrospray ionization-mass spectrometry(ESI-MS) was used to identify the gamma radiation-induced covalent cross-linking of model peptides (sequence YPPW and pYPPW) with the nucleobase thymine. Tandem electrospray ionization-mass spectrometry (ESI-MS") was employed to investigate the cross-linking sites. The results showed that irrespective of whether tyrosine was phosphorylated or not, the nucleobase thymine was cross-linked with the tryptophan residue. Possible cross-linking mechanisms are proposed by investigating the related mass peaks. Copyright (c) 2006 John Wiley & Sons, Ltd. |
| 语种 | 英语 ; 英语 |
| 出版者 | JOHN WILEY & SONS LTD ; CHICHESTER ; THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/13446]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Shi, Wei-Qun,Hu, Jia,Zhao, Wei,et al. Identification of radiation-induced cross-linking between thymine and tryptophan by electrospray ionization-mass spectrometry[J],2010, 2010. |
| APA | Shi, Wei-Qun.,Hu, Jia.,Zhao, Wei.,Su, Xiao-Yang.,Cai, Hui.,...&Li, Yan-Mei.(2010).Identification of radiation-induced cross-linking between thymine and tryptophan by electrospray ionization-mass spectrometry.. |
| MLA | Shi, Wei-Qun,et al."Identification of radiation-induced cross-linking between thymine and tryptophan by electrospray ionization-mass spectrometry".(2010). |
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