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	The self-assembly ability of the first microtubule-binding repeat from tau and its modulation by phosphorylation
	Zhou, Lian-Xiu ; Zeng, Zhi-Yang ; Du, Jin-Tang ; Zhao, Yu-Fen ; Li, Yan-Mei
	2010-05-06 ; 2010-05-06
关键词	Alzheimer's disease tau microtubule-binding repeat assembly phosphorylation PAIRED HELICAL FILAMENTS PROTEIN-TAU ALZHEIMERS-DISEASE ABNORMAL PHOSPHORYLATION NMR-SPECTROSCOPY PEPTIDE PHOSPHOPEPTIDES AGGREGATION ELUCIDATION TRANSITION Biochemistry & Molecular Biology Biophysics
中文摘要	Aggregation of abnormally phosphorylated tau in the form of tangs of paired helical filaments (PHFs) is one of the hallmarks of Alzheimer's disease (AD) and other tauopathies. It is of fundamental importance to study the mechanism of PHF formation and its modulation by phosphorylation. In this work, we have focused on the first microtubule-binding repeat of tau encompassing an abnormal phosphorylation site Ser(262). The assembly propensities of this repeat and its corresponding phosphorylated form were investigated by turbidity and electron microscopy. Additionally, conformation of the two peptides is also analyzed through circular dichroism (CD) and NMR spectroscopy. Our results reveal that both of them are capable of self-assembly and phosphorylation at Ser(262) could speed up the process of assembly. A possible mechanism of PHF formation is proposed and enhancing effect of phosphorylation on assembly provides an explanation to its toxicity in Alzheimer's disease. (c) 2006 Elsevier Inc. All rights reserved.
语种	英语 ; 英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE ; SAN DIEGO ; 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/13360]
专题	清华大学
推荐引用方式 GB/T 7714	Zhou, Lian-Xiu,Zeng, Zhi-Yang,Du, Jin-Tang,et al. The self-assembly ability of the first microtubule-binding repeat from tau and its modulation by phosphorylation[J],2010, 2010.
APA	Zhou, Lian-Xiu,Zeng, Zhi-Yang,Du, Jin-Tang,Zhao, Yu-Fen,&Li, Yan-Mei.(2010).The self-assembly ability of the first microtubule-binding repeat from tau and its modulation by phosphorylation..
MLA	Zhou, Lian-Xiu,et al."The self-assembly ability of the first microtubule-binding repeat from tau and its modulation by phosphorylation".(2010).

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