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	3-Aryl beta-carbolin-1-ones as a new class of potent inhibitors of tumor cell proliferation: synthesis and biological evaluation
	Wang, SZ ; Dong, YM ; Wang, XY ; Hu, XY ; Liu, JO ; Hu, YF
	2010-05-06 ; 2010-05-06
关键词	BETA-CARBOLINE ALKALOIDS PALLADIUM-CATALYZED CYCLIZATION EFFICIENT COPPER CATALYST 1ST TOTAL-SYNTHESIS ALPHA-AMINO-ACIDS ARYL HALIDES TERMINAL ACETYLENES INDOLE-DERIVATIVES GAMMA-CARBOLINE ENE-LACTAMS Chemistry, Organic
中文摘要	A novel three-step synthesis of 3-aryl beta-carbolin-1-ones from non-indole starting materials has been developed. The two nitrogen atoms in beta-carbolin-1-one were introduced efficiently by Michael addition of ethyl acetamidocyanoacetate to chalcone. The desired pyridone and indole rings were assembled by an intramolecular ketone nitrile annulation mediated by aqueous HCl-HOAc and a Cu(I)-catalyzed intramolecular N-arylation of the amide, respectively. The target compounds were found to possess significant activity against tumor cell proliferaton.
语种	英语 ; 英语
出版者	ROYAL SOC CHEMISTRY ; CAMBRIDGE ; THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/13299]
专题	清华大学
推荐引用方式 GB/T 7714	Wang, SZ,Dong, YM,Wang, XY,et al. 3-Aryl beta-carbolin-1-ones as a new class of potent inhibitors of tumor cell proliferation: synthesis and biological evaluation[J],2010, 2010.
APA	Wang, SZ,Dong, YM,Wang, XY,Hu, XY,Liu, JO,&Hu, YF.(2010).3-Aryl beta-carbolin-1-ones as a new class of potent inhibitors of tumor cell proliferation: synthesis and biological evaluation..
MLA	Wang, SZ,et al."3-Aryl beta-carbolin-1-ones as a new class of potent inhibitors of tumor cell proliferation: synthesis and biological evaluation".(2010).

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