| Layered solids as a ''molecular container'' for pharmaceutical agents: L-tyrosine-intercalated layered double hydroxides | |
| Wei, M ; Yuan, Q ; Evans, DG ; Wang, ZQ ; Duan, X | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | ION-EXCHANGE INTERCALATION AMINO-ACIDS PARKINSONS-DISEASE HYDROTALCITE RACEMIZATION SEPARATION ALUMINUM ANIONS CLAYS OXIDE Chemistry, Physical Materials Science, Multidisciplinary |
| 中文摘要 | L-Tyrosine has been intercalated into NiAl, MgAl and ZnAl layered double hydroxides by coprecipitation. The structure and composition of the intercalated materials have been characterized by X-ray diffraction (XRD) and elemental analysis. It is found that intercalation can inhibit racemization of L- tyrosine under the influence of sunlight, high temperature or ultraviolet light. Therefore, this layered material may have potential application as a "molecular container'' for storing or transporting unstable chiral biomolecules or pharmaceutical agents. In addition, the thermal decomposition of the L- tyrosine intercalated NiAl-LDH has been investigated in detail by means of in situ HT-XRD, in situ FT-IR and TG-DTA. Loss of interlayer water occurs between room temperature and 150 degreesC while decomposition of intercalated L- tyrosine and dehydroxylation of the host layers begin at about 250 degreesC and 300 degreesC respectively. |
| 语种 | 英语 ; 英语 |
| 出版者 | ROYAL SOC CHEMISTRY ; CAMBRIDGE ; THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/13001]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Wei, M,Yuan, Q,Evans, DG,et al. Layered solids as a ''molecular container'' for pharmaceutical agents: L-tyrosine-intercalated layered double hydroxides[J],2010, 2010. |
| APA | Wei, M,Yuan, Q,Evans, DG,Wang, ZQ,&Duan, X.(2010).Layered solids as a ''molecular container'' for pharmaceutical agents: L-tyrosine-intercalated layered double hydroxides.. |
| MLA | Wei, M,et al."Layered solids as a ''molecular container'' for pharmaceutical agents: L-tyrosine-intercalated layered double hydroxides".(2010). |
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