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	Ultrasensitive specific stimulant assay based on molecularly imprinted photonic hydrogels
	Hu, Xiaobin ; Li, Guangtao ; Li, Mohan ; Huang, Jing ; Li, Yan ; Gao, Yongbin ; Zhang, Yihe
	2010-05-06 ; 2010-05-06
关键词	DOPING CONTROL ANALYSIS HUMAN URINE MASS-SPECTROMETRY LIQUID-CHROMATOGRAPHY GAS-CHROMATOGRAPHY SENSING MATERIALS IONIC-STRENGTH POROUS GEL SOL-GEL POLYMERS Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter
中文摘要	Taking theophylline and (1R,2S)-(-)-ephedrine as template molecules, two imprinted photonic-hydrogel films are prepared by a combination of colloidal-crystal and molecular-imprinting techniques. This paper shows a new approach for rapid and handy stimulant detection with high sensitivity and specificity. One film is proposed for analogous molecule assay, another one for chiral recognition. The key point of this approach is that the imprinted photonic polymer (IPP) consists of a three-dimensional (313), highly-ordered and interconnected macroporous array with a thin hydrogel wall, where nanocavities complementary to analytes in shape and binding sites are distributed. This special, bicontinuous, hierarchical structure enables this polymer to report quickly, easily, sensitively and directly a molecular recognition event without any transducers and treatments for analytes (label-free). The I inherent affinity of the nanocavities, deriving from molecular imprinting, makes these sensors highly specific to analytes, even if in a competitive environment. Their sensitive and specific responses to stimulants in buffer are determined by Bragg diffractive shifts due to the lattice change of their 3D ordered macroporous arrays resulting from their preferential rebinding to the target molecules. The measurements show that the prepared hydrogel films exhibit high sensitivity in such a 0.1. fM concentration of analytes and specificity even in a competitive urinous buffer. The reported method provides a rapid and handy approach for stimulant assay and drug analysis in athletic sports.
语种	英语 ; 英语
出版者	WILEY-V C H VERLAG GMBH ; WEINHEIM ; PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/12850]
专题	清华大学
推荐引用方式 GB/T 7714	Hu, Xiaobin,Li, Guangtao,Li, Mohan,et al. Ultrasensitive specific stimulant assay based on molecularly imprinted photonic hydrogels[J],2010, 2010.
APA	Hu, Xiaobin.,Li, Guangtao.,Li, Mohan.,Huang, Jing.,Li, Yan.,...&Zhang, Yihe.(2010).Ultrasensitive specific stimulant assay based on molecularly imprinted photonic hydrogels..
MLA	Hu, Xiaobin,et al."Ultrasensitive specific stimulant assay based on molecularly imprinted photonic hydrogels".(2010).

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