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	Surface-Imprinted Nanostructured Layer-by-Layer Film for Molecular Recognition of Theophylline Derivatives
	Niu, Ha ; Liu, Zhihua ; Fu, Long ; Shi, Feng ; Ma, Hongwei ; Ozaki, Yukihiro ; Zhang, Xi
	2010-05-06 ; 2010-05-06
关键词	ATTACHED MULTILAYER ASSEMBLIES BIOMIMETIC SENSORS POLY(ACRYLIC ACID) BINDING-SITE DIAZO-RESINS POLYMERS TEMPLATES RECEPTOR POLYMERIZATION SELECTIVITY Chemistry, Physical
中文摘要	In this article we report the introduction of the cooperativity of various specific interactions combined with photo-cross-linking of the interlayers to yield binding sites that can realize better selectivity and imprinting efficiency of a surface molecularly imprinted LbL film (SMILbL), thus providing a new approach toward fabrication of nanostructured molecularly imprinted thin films. It involves preassembly of poly(acrylic acid) (PAA) conjugated of the theophylline residue template via a disulfide bridge, denoted as PAAtheo(15), in solution, and layer-by-layer (LbL) assembly of PAAtheo(15) and a positively charged photoreactive diazo resin (DAR) to form multilayer thin film with designed architecture. After photo-cross-linking of the film and template removal, binding sites specific to 7-(beta-hydroxyethyl)theophylline (Theo-ol) molecules are introduced within the film. Binding assay demonstrates that the SMILbL has a high selectivity of SMILbL to Theo-ol over caffeine. A control experiment demonstrates that the selectivity of SMILbL derives from nanostructured recognition sites among the layers. The imprinting amount per unit mass of the film can be 1 order of magnitude larger than that of the conventional bulk molecular imprinting systems. As this concept of construction SMILbL can be easily extended to the other molecules by the following similar protocol: its applications in building many other different molecular recognition systems are greatly anticipated.
语种	英语 ; 英语
出版者	AMER CHEMICAL SOC ; WASHINGTON ; 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/12758]
专题	清华大学
推荐引用方式 GB/T 7714	Niu, Ha,Liu, Zhihua,Fu, Long,et al. Surface-Imprinted Nanostructured Layer-by-Layer Film for Molecular Recognition of Theophylline Derivatives[J],2010, 2010.
APA	Niu, Ha.,Liu, Zhihua.,Fu, Long.,Shi, Feng.,Ma, Hongwei.,...&Zhang, Xi.(2010).Surface-Imprinted Nanostructured Layer-by-Layer Film for Molecular Recognition of Theophylline Derivatives..
MLA	Niu, Ha,et al."Surface-Imprinted Nanostructured Layer-by-Layer Film for Molecular Recognition of Theophylline Derivatives".(2010).

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