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	Synthesis, characterization, and controllable drug release of dendritic star-block copolymer by ring-opening polymerization and atom transfer radical polymerization
	Yuan, Weizhong ; Yuan, Jinying ; Zheng, Sixun ; Hong, Xiaoyin
	2010-05-06 ; 2010-05-06
关键词	dendritic star-block copolymer pH sensitivity controllable drug release TRIBLOCK COPOLYMER 2-(DIMETHYLAMINO)ETHYL METHACRYLATE L-LACTIDE POLYMERS ACID) INITIATORS CRYSTALLIZATION POLY(EPSILON-CAPROLACTONE) POLY(L-LACTIDE)S ARCHITECTURE Polymer Science
中文摘要	A series of well-defined dendritic star-block copolymers were successfully synthesized by combination of living ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP) with the hydroxyl-terminated dendrimer polyester. Dendritic star-shaped poly(L-lactide)s (PLLAs) were prepared by bulk polymerization of L-lactide (L-LA) with dendrimer polyester initiator and tin 2-ethylhexanoate catalyst. The number-average molecular weight of these polymers linearly increased with the molar ratio of L-LA to dendrimer initiator. Dendritic star-shaped PLLA was converted into a PLLABr macroinitiator with 2-bromopropionyl bromide. Dendritic star-block copolymers could be obtained via ATRP of 2-(N,N-dimethylamino)ethyl methacrylate (DMAEMA). The molecular weight distributions of these copolymers were narrow. The molecular weights of dendritic star-shaped polymers and star-block copolymers could be controlled by the molar ratios of monomer to initiator and monomer conversion. The thermal properties of these dendritic star-shaped polymers and star-block copolymers were investigated. The behavior of model drug chlorambucil release from the copolymer indicated that the rate of drug release could be effectively controlled by altering the pH values of the environment. (c) 2007 Elsevier Ltd. All rights reserved.
语种	英语 ; 英语
出版者	ELSEVIER SCI LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/12742]
专题	清华大学
推荐引用方式 GB/T 7714	Yuan, Weizhong,Yuan, Jinying,Zheng, Sixun,et al. Synthesis, characterization, and controllable drug release of dendritic star-block copolymer by ring-opening polymerization and atom transfer radical polymerization[J],2010, 2010.
APA	Yuan, Weizhong,Yuan, Jinying,Zheng, Sixun,&Hong, Xiaoyin.(2010).Synthesis, characterization, and controllable drug release of dendritic star-block copolymer by ring-opening polymerization and atom transfer radical polymerization..
MLA	Yuan, Weizhong,et al."Synthesis, characterization, and controllable drug release of dendritic star-block copolymer by ring-opening polymerization and atom transfer radical polymerization".(2010).

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