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	Synthesis of novel biomimetic Zwitterionic phosphorylcholine-bound chitosan derivative
	Zeng, R ; Fu, H ; Zhao, YF
	2010-05-06 ; 2010-05-06
关键词	biomimetic chitosan long-circulating macromolecular drug delivery (LCMDD) phosphorylcholine POLYSACCHARIDE NANOPARTICLES SOLUBILITY DELIVERY Polymer Science
中文摘要	Water-soluble biomimetic chitosan derivative conjugating zwitterionic phosphorylcholine was efficiently prepared through Atherton-Todd reaction under the mild conditions, and the possible formation mechanism of zwitterionic product was related to the nucleophilic attack of adjacent 3-hydroxyl on the D-glucosamine residue to phosphorus with the help of base. UV absorption and melting behaviors of DNA/phosphorylcholine-bound chitosan derivative showed that the phosphorylcholine-bound chitosan derivative could be a new carrier for long-circulating macromolecular drug delivery.
语种	英语 ; 英语
出版者	WILEY-V C H VERLAG GMBH ; WEINHEIM ; PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/12393]
专题	清华大学
推荐引用方式 GB/T 7714	Zeng, R,Fu, H,Zhao, YF. Synthesis of novel biomimetic Zwitterionic phosphorylcholine-bound chitosan derivative[J],2010, 2010.
APA	Zeng, R,Fu, H,&Zhao, YF.(2010).Synthesis of novel biomimetic Zwitterionic phosphorylcholine-bound chitosan derivative..
MLA	Zeng, R,et al."Synthesis of novel biomimetic Zwitterionic phosphorylcholine-bound chitosan derivative".(2010).

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