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	Synthesis of site-specifically dimethylated and trimethylated peptides derived from histone H3N-terminal tail
	Huang, ZP ; Du, JT ; Zhao, YF ; Li, YM
	2010-05-06 ; 2010-05-06
关键词	lysine methylation quaternisation methylated peptide histone LYSINE METHYLATION H3 PROTEINS Biochemistry & Molecular Biology
中文摘要	Lysine methylation within the N-terminal tail region of histories is associated with various biological processes ranging from transcriptional regulation to epigenetic silencing. In order to investigate biological functions of methylation, specific lysine dimethylated and trimethylated peptides derived from histone H3 N-terminal tail have been successfully synthesized by incorporating N-alpha-Fmoc-N-epsilon-dimethyl-lysine or N-alpha-Fmoc-N-epsilon-trimethyl-lysine as building blocks via solid-phase peptide synthesis. Facile synthesis of N-alpha-Fmoc-N-epsilon-dimethyl-lysine and N-alpha-Fmoc-N-epsilon-trimethyl-lysine have been presented. Reductive methylation of N-Fmoc-lysine gives N-alpha-Fmoc-N-epsilon-dimethyl-lysine. Quaternisation of N-alpha-Fmoc-lysine or N-alpha-Fmoc-N-epsilon-dimethyl-lysine produces N-alpha-Fmoc-N-epsilon-trimethyl-lysine as an iodide salt.
语种	英语 ; 英语
出版者	SPRINGER ; NEW YORK ; 233 SPRING STREET, NEW YORK, NY 10013 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/12333]
专题	清华大学
推荐引用方式 GB/T 7714	Huang, ZP,Du, JT,Zhao, YF,et al. Synthesis of site-specifically dimethylated and trimethylated peptides derived from histone H3N-terminal tail[J],2010, 2010.
APA	Huang, ZP,Du, JT,Zhao, YF,&Li, YM.(2010).Synthesis of site-specifically dimethylated and trimethylated peptides derived from histone H3N-terminal tail..
MLA	Huang, ZP,et al."Synthesis of site-specifically dimethylated and trimethylated peptides derived from histone H3N-terminal tail".(2010).

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