| Studies of interaction between a new synthesized minor-groove targeting artificial nuclease and DNA | |
| Yin, Qiang ; Zhang, Zhen ; Zhao, Yu-Fen | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | DNA binding polyamide bioconjugate UV-vis spectroscopy circular dichroism DODECAMER D(CGCAAATTTGCG) CIRCULAR-DICHROISM RECOGNITION DISTAMYCIN BINDING NETROPSIN ANALOGS COMPLEX Spectroscopy |
| 中文摘要 | Nuclease plays an important role in molecular biology, such as DNA sequencing. Synthetic polyamide conjugates can be considered as new too] in the selective inhibition of gene expression and as potential drugs in anticancer or antiviral chemotherapy. In this paper, a new synthesized minor-groove targeting artificial nuclease, oligopyrrol-containing peptide, was reported. It was found that this new compound can bind DNA in AT-riched minor groove with high affinity and site specificity. DNA binding behavior was determined by UV-vis and circular dichroism (CD) methods. It was indicated that compound 6 can enhance the T-m of oligomer DNA from 51.8 to 63.5 degrees C and possesses large binding constant (K-b = 8.83 x 10(4) L/mol). (c) 2006 Elsevier B.V. All rights reserved. |
| 语种 | 英语 ; 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD ; OXFORD ; THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/12330]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Yin, Qiang,Zhang, Zhen,Zhao, Yu-Fen. Studies of interaction between a new synthesized minor-groove targeting artificial nuclease and DNA[J],2010, 2010. |
| APA | Yin, Qiang,Zhang, Zhen,&Zhao, Yu-Fen.(2010).Studies of interaction between a new synthesized minor-groove targeting artificial nuclease and DNA.. |
| MLA | Yin, Qiang,et al."Studies of interaction between a new synthesized minor-groove targeting artificial nuclease and DNA".(2010). |
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