| Studies on a novel minor-groove targeting artificial nuclease: Synthesis and DNA binding behavior | |
| Yin Qiang ; Zhang Zhen ; Zhao Yu-fen | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | calf thymus DNA polyamide bioconjugate UV-Vis spectroscopy circular dichroism CIRCULAR-DICHROISM RECOGNITION LIGANDS ANALOGS Chemistry, Multidisciplinary |
| 中文摘要 | Nucleases play an important role in molecular biology, for example, in DNA sequencing. Synthetic polyamide conjugates can be considered as a novel tool for the selective inhibition of gene expressions and also as potential drugs in anticancer or antiviral chemotherapy. In this article, the synthesis of a novel minor-groove targeting artificial nuclease, an oligopyrrol-containing compound, has been reported. It was found that this novel compound can bind DNA in AT-rich minor groove with high affinity and site specificity. DNA binding behavior was determined by using UV-Vis and CD. It is indicated that compound 6 can enhance the T of DNA from 80.4 degrees C to 84.4 degrees C and that it possesses a high binding constant value(Kb = 3.05 x 10(4) L/mol) |
| 语种 | 英语 ; 英语 |
| 出版者 | HIGHER EDUCATION PRESS ; BEIJING ; SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/12291]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Yin Qiang,Zhang Zhen,Zhao Yu-fen. Studies on a novel minor-groove targeting artificial nuclease: Synthesis and DNA binding behavior[J],2010, 2010. |
| APA | Yin Qiang,Zhang Zhen,&Zhao Yu-fen.(2010).Studies on a novel minor-groove targeting artificial nuclease: Synthesis and DNA binding behavior.. |
| MLA | Yin Qiang,et al."Studies on a novel minor-groove targeting artificial nuclease: Synthesis and DNA binding behavior".(2010). |
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