| Simultaneous determination of geniposide, baicalin, cholic acid and hyodeoxycholic acid in rat serum for the pharmacokinetic investigations by high performance liquid chromatography-tandem mass spectrometry | |
| Ran, Xiaorong ; Liang, Qionglin ; Luo, Guoan ; Liu, Qingfei ; Pan, Yanshu ; Wang, Bing ; Pang, Chunhong | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | HPLC-MS-MS geniposide baicalin cholic acid hyodeoxycholic acid pharmacokinetics PLASMA BILE Biochemical Research Methods Chemistry, Analytical |
| 中文摘要 | A simple, rapid, and specific analytical method for simultaneous determination of geniposide, baicalin, cholic acid and hyodeoxycholic acid in 50 RL samples of rat serum was developed by high performance liquid chromatography-tandem mass spectrometry. The quantification of the target compounds was determined by multiple reaction monitoring (MRM) mode using electrospray ionization (ESI). The correlation coefficients of the calibration curves were better than 0.997. The intra- and inter-day accuracy, precision, and linear range had been investigated in detail. This method was subsequently applied to pharmacokinetic studies of geniposide, baicalin, cholic acid and hyodeoxycholic acid in rats successfully. (c) 2006 Elsevier B.V All rights reserved. |
| 语种 | 英语 ; 英语 |
| 出版者 | ELSEVIER SCIENCE BV ; AMSTERDAM ; PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/12230]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Ran, Xiaorong,Liang, Qionglin,Luo, Guoan,et al. Simultaneous determination of geniposide, baicalin, cholic acid and hyodeoxycholic acid in rat serum for the pharmacokinetic investigations by high performance liquid chromatography-tandem mass spectrometry[J],2010, 2010. |
| APA | Ran, Xiaorong.,Liang, Qionglin.,Luo, Guoan.,Liu, Qingfei.,Pan, Yanshu.,...&Pang, Chunhong.(2010).Simultaneous determination of geniposide, baicalin, cholic acid and hyodeoxycholic acid in rat serum for the pharmacokinetic investigations by high performance liquid chromatography-tandem mass spectrometry.. |
| MLA | Ran, Xiaorong,et al."Simultaneous determination of geniposide, baicalin, cholic acid and hyodeoxycholic acid in rat serum for the pharmacokinetic investigations by high performance liquid chromatography-tandem mass spectrometry".(2010). |
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