| Copper (II) modulates in vitro aggregation of a tau peptide | |
| Zhou, Lian-Xiu ; Du, Jin-Tang ; Zeng, Zhi-Yang ; Wu, Wei-Hui ; Zhao, Yu-Fen ; Kanazawa, Kenji ; Ishizuka, Yasuko ; Nemoto, Tadashi ; Nakanishi, Hiroshi ; Li, Yan-Mei | |
| 2010-05-06 ; 2010-05-06 | |
| 关键词 | tau protein Alzheimer's disease copper aggregation PAIRED HELICAL FILAMENTS ALZHEIMERS-DISEASE AMYLOID-BETA ABNORMAL PHOSPHORYLATION NMR-SPECTROSCOPY METAL-BINDING PROTEIN-TAU PRION POLYMERIZATION SEQUENCE Biochemistry & Molecular Biology Pharmacology & Pharmacy |
| 中文摘要 | Copper (II) has been implicated in the pathology of Alzheimer's disease (AD) for the impaired homeostatic mechanism found in the brains of AD patients. Here we studied the binding properties of Cu(II) with the first microtubule-binding repeat, encompassing residues 256-273 of the human tau441 sequence. Additionally, the effect of Cu(II) on the assembly of this repeat was also investigated. Our results indicate that Cu(II) can bind to this repeat with His(268) involved and has an inhibiting effect on the in vitro aggregation of this repeat. This work provides new insight into the role of Cu(II) in Alzheimer's disease. (C) 2007 Elsevier Inc. All rights reserved. |
| 语种 | 英语 ; 英语 |
| 出版者 | ELSEVIER SCIENCE INC ; NEW YORK ; 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA |
| 内容类型 | 期刊论文 |
| 源URL | [http://hdl.handle.net/123456789/12205]  |
| 专题 | 清华大学 |
| 推荐引用方式 GB/T 7714 | Zhou, Lian-Xiu,Du, Jin-Tang,Zeng, Zhi-Yang,et al. Copper (II) modulates in vitro aggregation of a tau peptide[J],2010, 2010. |
| APA | Zhou, Lian-Xiu.,Du, Jin-Tang.,Zeng, Zhi-Yang.,Wu, Wei-Hui.,Zhao, Yu-Fen.,...&Li, Yan-Mei.(2010).Copper (II) modulates in vitro aggregation of a tau peptide.. |
| MLA | Zhou, Lian-Xiu,et al."Copper (II) modulates in vitro aggregation of a tau peptide".(2010). |
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