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	Cleavage of gamma DNA by seryl-histidine planted peptide dendrimer
	He Jun ; Ma Yuan ; Zhao Yu-Fen
	2010-05-06 ; 2010-05-06 ; OCT
关键词	DIPEPTIDE Chemistry, Multidisciplinary
中文摘要	Artificial nucleic acid cleavage agents have received considerable attention due to their very important applications in biochemistry and molecular biology. Seryl-histidine is a dipeptide possessing DNA, protein and ester cleavage activity. Since peptide dendrimers have a lot of unique physical and chemical properties compared to normal peptide chain and have a great varieties of applications in biological areas, two and four branched seryl-histidine planted peptide dendrimers were synthesized by Fmoc solid phase peptide synthesis approach. The products were purified by HPLC and characterized by ESI-MS. Their DNA cleavage activities. Were tested by means of Agarose Gel Electrophoresis. In the cleavage reaction, peptide dendrimer showed a strong combining inclination to DNA, highly concentrated dendrimer solution can quench the fluorescence of EB. Even though, the DNA cleavage activity of the dendrimers was lower than that of seryl-histidine dipeptide monomer.
语种	中文 ; 中文
出版者	HIGHER EDUCATION PRESS ; BEIJING ; SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/12143]
专题	清华大学
推荐引用方式 GB/T 7714	He Jun,Ma Yuan,Zhao Yu-Fen. Cleavage of gamma DNA by seryl-histidine planted peptide dendrimer[J],2010, 2010, OCT.
APA	He Jun,Ma Yuan,&Zhao Yu-Fen.(2010).Cleavage of gamma DNA by seryl-histidine planted peptide dendrimer..
MLA	He Jun,et al."Cleavage of gamma DNA by seryl-histidine planted peptide dendrimer".(2010).

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