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Neural network approach to predict RNA secondary structures
Zhang Xiuwei ; Deng Zhidong ; Song Dandan
2010-05-06 ; 2010-05-06
关键词Practical Theoretical or Mathematical/ backpropagation biology computing computational complexity context-free grammars macromolecules neural nets organic compounds/ RNA secondary structures ribonucleic acid stochastic context-free grammar BP neural network computational complexity/ A8715B Biomolecular structure, configuration, conformation, and active sites C7330 Biology and medical computing C4210L Formal languages and computational linguistics C5290 Neural computing techniques C4240C Computational complexity
中文摘要Ribonucleic acid (RNA) secondary structure predictions based on stochastic context-free grammar (SCFG) models are very complex. This paper presents a BP neural network approach for predicting RNA secondary structures based on a new representation of the RNA structure information. The new format for the secondary structure prediction results can be easily converted to the commonly used CT format. Test results obtained with tRNA training and testing datasets show that the approach has higher prediction accuracy and greater correlation coefficients than the two best-performance SCFG models. Since computational complexity for heuristic neural network approaches are relatively simple, the method can be used to solve secondary structure prediction problems of long RNA sequences with lengths greater than 1000 nt, which are difficult with traditional folding algorithms.
语种中文 ; 中文
出版者Tsinghua Univ. Press ; China
内容类型期刊论文
源URL[http://hdl.handle.net/123456789/9814]  
专题清华大学
推荐引用方式
GB/T 7714
Zhang Xiuwei,Deng Zhidong,Song Dandan. Neural network approach to predict RNA secondary structures[J],2010, 2010.
APA Zhang Xiuwei,Deng Zhidong,&Song Dandan.(2010).Neural network approach to predict RNA secondary structures..
MLA Zhang Xiuwei,et al."Neural network approach to predict RNA secondary structures".(2010).
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