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	Alteration of protein subcellular location and domain formation by alternative translational initiation
	Cai, J ; Huang, Y ; Li, F ; Li, YD
	2010-05-06 ; 2010-05-06
关键词	alternative translation initiation events nucleotide context subcellular relocalization domain contents MESSENGER-RNA SEQUENCES MAMMALIAN-CELLS START CODON AUG CODONS LOCALIZATION ISOFORMS VIRUS CUG RIBOSOMES RECEPTOR Biochemistry & Molecular Biology Biophysics
中文摘要	Alternative translation is an important cellular mechanism contributing to the generation of proteins and the diversity of protein functions. Instead of studying individual cases, we systematically analyzed the alteration of protein subcellular location and domain formation by alternative translational initiation in eukaryotes. The results revealed that 85.7% of alternative translation events generated biological diversity, attributed to different subcellular localizations and distinct domain contents in alternative isoforms. Analysis of isoelectric point values revealed that most N-terminal truncated isoforms significantly lowered their isoelectric point values targeted at different subcellular localizations, whereas they had conserved domain contents the same as the full-length isoforms. Furthermore, Fisher's exact test indicated that the two ways-targeting at different cellular compartments and changing domain contents-were negatively associated. The N-term truncated isoforms should have only one way to diversify their functions distinct from the full-length ones. The peculiar consequence of subcellular relocation as well as change of domain contents reflected the very high level of biological complexity as alternative usage of initiation codons.
语种	英语 ; 英语
出版者	WILEY-LISS ; HOBOKEN ; DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/9230]
专题	清华大学
推荐引用方式 GB/T 7714	Cai, J,Huang, Y,Li, F,et al. Alteration of protein subcellular location and domain formation by alternative translational initiation[J],2010, 2010.
APA	Cai, J,Huang, Y,Li, F,&Li, YD.(2010).Alteration of protein subcellular location and domain formation by alternative translational initiation..
MLA	Cai, J,et al."Alteration of protein subcellular location and domain formation by alternative translational initiation".(2010).

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