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	Prediction of C-to-U RNA editing sites in plant mitochondria using both biochemical and evolutionary information
	Du, Pufeng ; Li, Yanda
	2010-05-06 ; 2010-05-06
关键词	CURE KNN homology search AMINO-ACID-COMPOSITION PROTEIN SUBCELLULAR LOCATION PENTATRICOPEPTIDE REPEAT PROTEIN COMPLETE NUCLEOTIDE-SEQUENCE ARABIDOPSIS-THALIANA ENSEMBLE CLASSIFIER SUBNUCLEAR LOCATION SIGNAL PEPTIDES CIS-ELEMENTS LAND PLANTS Biology Mathematical & Computational Biology
中文摘要	Although cytidine-to-uridine conversions in plant mitochondria were discovered 18 years ago, it was still an enigmatic process. Since the sequencing projects of plant mitochondrial genomes are providing more and more available sequences, the requirements of computationally identifying C-to-U RNA editing sites are also increasing. By incorporating both evolutionary and biochemical information, we developed a novel algorithm for predicting C-to-U RNA editing sites in plant mitochondria. The algorithm has been implemented as an online service called CURE (Cytidine-to-Uridine Recognizing Editor). CURE performs better than other methods that are based on only biochemical or only evolutionary information. CURE also provides the ability of predicting C-to-U RNA editing sites in non-coding regions and the synonymous C-to-U RNA editing sites in coding regions that are impossible for other methods. Furthermore, CURE can carry out prediction directly on the entire mitochondria genome sequence. The prediction results of CURE suggest the functional importance of synonymous RNA editing sites, which was neglected before. The CURE service can be accessed at . (C) 2008 Elsevier Ltd. All rights reserved.
语种	英语 ; 英语
出版者	ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD ; LONDON ; 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/9039]
专题	清华大学
推荐引用方式 GB/T 7714	Du, Pufeng,Li, Yanda. Prediction of C-to-U RNA editing sites in plant mitochondria using both biochemical and evolutionary information[J],2010, 2010.
APA	Du, Pufeng,&Li, Yanda.(2010).Prediction of C-to-U RNA editing sites in plant mitochondria using both biochemical and evolutionary information..
MLA	Du, Pufeng,et al."Prediction of C-to-U RNA editing sites in plant mitochondria using both biochemical and evolutionary information".(2010).

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