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	Network-based global inference of human disease genes
	Wu, Xuebing ; Jiang, Rui ; Zhang, Michael Q. ; Li, Shao
	2010-05-06 ; 2010-05-06
关键词	disease gene human disease modularity network prioritization BREAST-CANCER SUSCEPTIBILITY PROTEIN INTERACTION NETWORK CANDIDATE GENES HUMAN PHENOME MENDELIAN-INHERITANCE INTERACTION DATABASE COLORECTAL CANCERS HUMAN PHENOTYPES EXPRESSION COMPLEX Biochemistry & Molecular Biology
中文摘要	Deciphering the genetic basis of human diseases is an important goal of biomedical research. On the basis of the assumption that phenotypically similar diseases are caused by functionally related genes, we propose a computational framework that integrates human protein-protein interactions, disease phenotype similarities, and known gene-phenotype associations to capture the complex relationships between phenotypes and genotypes. We develop a tool named CIPHER to predict and prioritize disease genes, and we show that the global concordance between the human protein network and the phenotype network reliably predicts disease genes. Our method is applicable to genetically uncharacterized phenotypes, effective in the genome-wide scan of disease genes, and also extendable to explore gene cooperativity in complex diseases. The predicted genetic landscape of over 1000 human phenotypes, which reveals the global modular organization of phenotype genotype relationships. The genome-wide prioritization of candidate genes for over 5000 human phenotypes, including those with under-characterized disease loci or even those lacking known association, is publicly released to facilitate future discovery of disease genes.
语种	英语 ; 英语
出版者	NATURE PUBLISHING GROUP ; NEW YORK ; 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA
内容类型	期刊论文
源URL	[http://hdl.handle.net/123456789/8967]
专题	清华大学
推荐引用方式 GB/T 7714	Wu, Xuebing,Jiang, Rui,Zhang, Michael Q.,et al. Network-based global inference of human disease genes[J],2010, 2010.
APA	Wu, Xuebing,Jiang, Rui,Zhang, Michael Q.,&Li, Shao.(2010).Network-based global inference of human disease genes..
MLA	Wu, Xuebing,et al."Network-based global inference of human disease genes".(2010).

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